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High Throughput Cellular Screening for Development of Post-Transcriptonal Gene Silencing Agents against Arbitrary mRNA Targets

The development of RNA based therapies suffers from a bottleneck in identifying lead candidates that significantly knockdown target RNA in vivo. This is primarily due to the difficulties in predicting the dynamic secondary and tertiary structure of RNA. Currently, researchers begin by using software programs such as MFold and SFold. However, these...
Published: 5/31/2012   |   Inventor(s): Jack Sullivan, Edwin Yau
Keywords(s): Technology
Category(s): Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines, Campus > University at Buffalo

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