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for "therapeutics"
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PI 3-Kinase Cancer Immunotherapy

Pancreatic cancer patients will be treated with a PI3K inhibitor to induce the cancer cells to reveal their antigens to the immune system Background: Standard chemotherapies have little impact on pancreatic cancer (PDAC) patient survival, and new T-cell therapies have yet to be successful in treating solid tumors. Phosphoinositide 3-kinase...
Published: 8/28/2020   |   Inventor(s): Richard Lin
Keywords(s): cancer, immunotherapy, phosphoinositide 3-kinase (PI3K), PI3K inhibitors, Technologies
Category(s): Gene Therapy and Viral Vectors, Therapeutics, Campus > Stony Brook University

Method of Treating Alzheimer's Disease with X-ray Minibeams

An x-ray therapy method for treating Alzheimer's disease that maintains a tissue-sparing effect allowing for higher doses Background: Alzheimer’s Disease is the most common form of dementia among the elderly and affects over five million individuals in the United States. To date, there is no definitive treatment to cure or halt the progression...
Published: 8/28/2020   |   Inventor(s): Avraham Dilmanian, Renee Cattell, Lev Bangiyev
Keywords(s): cell differentiation, computed tomography (CT) scanner, glial progenitor cells, radiation therapy, Technologies, tissue-sparing effect, x-ray microbeams
Category(s): Therapeutics, Medical Devices, Campus > Stony Brook University

Novel Prodrugs for Selective Anticancer Therapy

Novel methods to make anticancer prodrugs by conjugating unique dual-substrate biochemical modules to known or novel chemotherapeutic drugs Background: Anticancer drug sales exceeded $50 billion worldwide in 2009 with impressive growth; however, lack of target selectivity is a major challenge in cancer treatment. The limitation of current...
Published: 8/27/2020   |   Inventor(s): Michael Hayman, Nobuhide Ueki
Keywords(s): anticancer drugs, cancer-associated protease, HDAC, nucleoside analogues, Technologies
Category(s): Therapeutics, Drug Delivery, Drug Design and/or Synthesis, Campus > Stony Brook University

Crosslinked Thermoreversible Pluronic Hydrogels for Prosthetic Disc Nucleus Replacement

An easily injectable crosslinked hyaluronic acid-gelatin hydrogel that can be used as a prosthetic replacement for a spinal disc nucleus Background: When a spinal disc becomes damaged due to trauma or disease resulting in a disc herniation, it may become necessary to replace a natural spinal disc nucleus with a prosthesis. Such prostheses should preferably...
Published: 8/27/2020   |   Inventor(s): Miriam Rafailovich, Raphael Davis, Divya Bhatnagar
Keywords(s): Gelatin, Hyaluronic Acid, Hydrogels, Pluronic, Spinal Disc, Technologies, thermoreversible
Category(s): Therapeutics, Medical Devices, Material and Composites, Campus > Stony Brook University

Enhancing Responses to Chemical Interventions by Programmed Introduction of Multiple Refractory Periods

A medical device that can deliver multiple, brief intervention doses over a 24 hour period that improves cell biologic responses. Background: The ability of any exogenous intervention, be it physical or chemical in nature, to influence cell activity is markedly enhanced by incorporating a rest period between stimulation periods within any given 24 hour...
Published: 8/27/2020   |   Inventor(s): Clinton Rubin
Keywords(s): Adaptation, Adipogenesis, Adult Stem Cells, Augmentation, Bioelectrical, Bioengineering, Biological, Biomechanical, Biomedical or Biotechnology, Device, Enhancement, Intervention, Mechanical, Mesenchymal Stem Cells, Non-invasive, Osteogenesis, Pharmaceutical, Repair, Stimulation, Technologies, Timing, Tissue
Category(s): Medical Devices, Therapeutics, Campus > Stony Brook University

Methods of Treating and Preventing Angioedema and Vascular Leakage

Peptides and antibodies that block vascular permeability induced in angioedema patients that are new targets for treatment. Background: Angioedema associated with C1-INH deficiency is an inherited or acquired condition that affects 20 per cent of the population. The condition can be disfiguring, painful and sometimes fatal. Existing treatments primarily...
Published: 8/27/2020   |   Inventor(s): Berhane Ghebrehiwet
Keywords(s): angioedema, gClqR, Medical, Monoclonal antibody, peptides, Technologies, vascular leakage
Category(s): Therapeutics, Antibodies, Campus > Stony Brook University

Enzymatic Capsulotomy for Shoulder Adhesive Capsulitis

A minimally invasive collagenase injection method for treating frozen shoulder that is cost-effective Background: Adhesive capsulitis of the shoulder, more commonly known as frozen shoulder, results in painful limitation of shoulder motion. It can arise idiopathically or after trauma. The current standard of care is a long course of painful physical...
Published: 8/27/2020   |   Inventor(s): Marie Badalamente, Edward Wang
Keywords(s): Collagenase Injection, Frozen shoulder, Nonoperative Therapy, Technologies
Category(s): Drug Design and/or Synthesis, Therapeutics, Campus > Stony Brook University

Novel Method For Enzymatic Production of Cyclic-diGMP

Enzymes for synthesizing large quantities of cyclic-diGMP that are low cost and retain enzymatic activity for several months Background: Cyclic bis (3’,5’) diguanylate monophosphate or (cyclic-diGMP) is a bacterial secondary messenger involved in the regulation of various cellular processes that have medical and agricultural implications...
Published: 8/27/2020   |   Inventor(s): Elizabeth Boon, Natasha Nesbitt, Roger Johnson
Keywords(s): c-di-GMP, cyclic diguanylate monophosphate, diguanylate cyclase, Technologies
Category(s): Therapeutics, Research Tools and Reagents, Campus > Stony Brook University

Novel Compounds and Methods for Treating Invasive Fungal Infections

Compounds that decrease the synthesis of glucosylceramide, a sphingolipid that promotes fungal infection Background: With the increasing number of immunodeficient subjects and the increase of the lifespan of these subjects due to the advance in medicine, there has been a concomitant rise in the number of cases of life-threatening fungal...
Published: 8/25/2020   |   Inventor(s): Maurizio Del Poeta, Visesato Mor
Keywords(s): antifungal, fungal infection, glucosylceramide, sphingolipid, Technologies
Category(s): Therapeutics, Campus > Stony Brook University

Fungal Glucosylceramide as a Vaccine for Fungal Infections

Purified lipid extracted from nonpathogenic fungal cells as an antigen to stimulate the host immunity Background: Fungal infections pose a significant threat to public health. Fungi are common in the environment, as they can thrive in soil, on plants and trees, and on animate objects, including human skin. Despite the availability of antifungal agents,...
Published: 8/25/2020   |   Inventor(s): Maurizio Del Poeta, Visesato Mor
Keywords(s): cerebroside, fungal infection, glucosylceramide, sphingolipid, Technologies
Category(s): Therapeutics, Campus > Stony Brook University
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