An MRI based Approach to Map Blood Brain Barrier Permeability in Human Subjects
Blood-brain barrier (BBB) disruption may be the key mechanism leading to neuronal dysfunction in neurological and psychiatric disorders including multiple sclerosis (MS), Parkinson’s (PD), Alzheimer’s (AD), bipolar, autism, schizophrenia and epilepsy. Existing approaches to measure BBB integrity often involves toxic exogenous contrast agents and requires ionizing radiation. Their sensitivity is very limited to detect the subtle BBB disruption in most psychiatric diseases. Therefore, a capability of non-invasive in vivo mapping of BBB integrity in human patients is of high clinical significance.
Inventors at Stony Brook University (SBU) have developed a novel magnetic resonance imaging (MRI) based acquisition and post-processing protocol, Intrinsic Diffusivity Encoding of Arterial Labeled Spins (IDEALS), that would enable clinicians to non-invasively map BBB water permeability with full brain coverage. The IDEALS protocol has been successfully utilized to detect BBB abnormality in patients with multiple sclerosis and patients with major depressive disorders.
Direct measurement of BBB water permeability, the most sensitive assessment of BBB disfunction in all neurological and psychiatric disorders
MRI-based non-invasive without any toxic contrast
neurological and psychiatric disorders
Monitoring drug efficacy in clinical trial
A US Provisional Patent Application Filed
Available for License
MRI Imaging l BBB l Neurological disorders l Patient Stratification
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