An MRI-based Approach to Map Blood-Brain Barrier Permeability in Human Subjects

An MRI based Approach to Map Blood Brain Barrier Permeability in Human Subjects

Blood-brain barrier (BBB) disruption may be the key mechanism leading to neuronal dysfunction in neurological and psychiatric disorders including multiple sclerosis (MS), Parkinson’s (PD), Alzheimer’s (AD), bipolar, autism, schizophrenia and epilepsy. Existing approaches to measure BBB integrity often involves toxic exogenous contrast agents and requires ionizing radiation. Their sensitivity is very limited to detect the subtle BBB disruption in most psychiatric diseases. Therefore, a capability of non-invasive in vivo mapping of BBB integrity in human patients is of high clinical significance.

Inventors at Stony Brook University (SBU) have developed a novel magnetic resonance imaging (MRI) based acquisition and post-processing protocol, Intrinsic Diffusivity Encoding of Arterial Labeled Spins (IDEALS), that would enable clinicians to non-invasively map BBB water permeability with full brain coverage. The IDEALS protocol has been successfully utilized to detect BBB abnormality in patients with multiple sclerosis and patients with major depressive disorders.

Direct measurement of BBB water permeability, the most sensitive assessment of BBB disfunction in all neurological and psychiatric disorders

MRI-based non-invasive without any toxic contrast

neurological and psychiatric disorders

Health Care

Diagnostics

Emergency Medicine

Monitoring drug efficacy in clinical trial

A US Provisional Patent Application Filed

Available for License

MRI Imaging l BBB l Neurological disorders l Patient Stratification

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