CASA antibacterial regenerative paste

This endodontic paste has improved antibacterial efficacy and limited cytotoxicity Background: _E.faecalis_ is the most commonly implicated microorganism in asymptomatic persistent endodontic infection. The highly complex nature of the organism coupled with its ability to survive extreme conditions of pH, high salt and prolonged nutritional deprivations renders traditional practices, such as, use of calcium hydroxide inefficient. Given the growing patient population, there is an urgent need to develop an effective agent against E.faecalis and other bacteria that are linked to endodontic infections. Technology Overview: Stony Brook University have identified a precise combination of two antibacterial agents that can overcome existing challenges associated with the use of calcium hydroxide. Salicylic acid, a known proton pump inhibitor, when mixed with calcium hydroxide at a specific ratio creates not only an improved anti-bacterial paste against _E.faecalis_, but also brings down the pH to near neutral thereby helping in limiting cytotoxicity of the combination product. Advantages: -Increased antibacterial activity

-Limited cytotoxicity

-Neutral range of pH

-Expected to have affordable price range Applications: Dentistry: - Root canal therapy - direct pulp capping - intra-visit root canal dressing - apexification #050-8994 Intellectual Property Summary: Provisional patent Stage of Development: US Provisional Patent Filed. Licensing Potential: Licensing Status: Additional Information: dental,antibacterial,cytotoxicity,antibacterial agent,anti-bacterial,dentistry,root canal,dental medicine,dental innovations,dental hygiene,dental health,dental solutions,endodontics,clinical dentistry,antibacterials,oral hygiene,oral bacteria,oral health,oral health care,oral medicine https://stonybrook.technologypublisher.com/files/sites/yv62rpcqthqzvd333zgq_root_canal_on_a_patient.jpg Please note, header image is purely illustrative. Source: Ruth Holcomb, U.S. Air Force. Wikimedia Commons, public domain

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