Device to Control Drug Delivery of Wet Aerosols

Efficient Nebulizer chamber which allows control of the inhaled mass of the drug, the need for breath actuation, the breathing pattern, and the particle distribution. Background: The disadvantages of wet nebulizers are well known. While they allow flexibility in drug delivery, they require compressed gas, they are inefficient and they generate polydisperse aerosols. A modern solution is the vibrating mesh nebulizer which do not require compressed gas and is capable of high efficiency. However, from a practical point of view, an efficient vibrating mesh system can be just as inefficient as a typical jet nebulizer. In addition, the particles from vibrating systems can be more polydisperse and variable from than aerosols from jet nebulizers. The goal of the new device is to deliver wet aerosols efficiently to humans with minimal losses, independently of breathing pattern and with a reduced treatment time. Technology Overview: The deposition of inhaled drugs in the lungs is affected by many factors, particularly the efficiency of the device, the size of the generated particles, mixing of the aerosol with room air, the breathing pattern, and the inter-device variability of the nebulizer itself. Dr. Gerald Smaldone, Professor of Medicine at Stony Brook University has designed a chamber that mitigates many of these issues. The proposed invention also allows control of many factors without sophisticated electronics, including the inhaled mass of the drug, the need for breath actuation, the breathing pattern, and the particle distribution. Advantages: Independant of breathing pattern. Does not require breath actuation. Does not require sophisticated technology to control breathing. Applications: Efficient nebulizer which allows control of the inhaled mass of the drug, the need for breath actuation, the breathing pattern, and the particle distribution. Intellectual Property Summary: PCT Pending Stage of Development: Prototype developed and available for testing. Licensing Potential: We seek to develop and commercialize, by an exclusive or non-exclusive license agreement and/or sponsored research, with a company active in the area. Licensing Status: Available for License Additional Information: Particle distribution, Nebulizer, Humidity, Ultrasonic mesh https://stonybrook.technologypublisher.com/files/sites/drug-delivery1.jpg , https://stonybrook.technologypublisher.com/files/sites/drug-design-&-synthesis1.jpg , https://stonybrook.technologypublisher.com/files/sites/it-21.jpg
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