Near Infrared Flourescence as a Guide for Nephrostomy Access in Rats
Upstate Medical University researchers have developed a simple, safe, and cost
effective solution to be used in near infra-red tissue imaging.
at SUNY Upstate Medical University have developed an improved fluorescent
compound used tissue imaging. Typical imaging of renal tissue is conducted using
a common fluorophore in medical diagnostics - indocyanine green - and near
infra-red light. This method however does not yield a strong signal to
background ratio. As a result imaging tissue like ureters, is limited during
pelvic surgery. Finding a solution that fluoresces at a greater intensity would
be of great value to surgeons.
Upstate’s novel solution for tissue imaging involves the use of indocyanine
green and powdered milk. Our researchers have found the optimal blend of these
two compounds to yield a significantly enhanced signal to background ratio. This
technology is particularly valuable because both compounds are already approved
for use in humans by the FDA. Furthermore, these compounds are easy to procure
and cost efficient. This technology provides a significant advantage over the
use of indocyanine green alone.