Novel miR-129 Based Cancer Therapeutics

The miR-129 mimic shows enhanced abilities to disrupt resistant cancer cell proliferation and induction of cell cycle arrest. Background: In the last 15 years, it has become well established that microRNAs play important roles in cancer biology. Due to their ability to regulate the expression of important target genes, aberrant expression of miRNAs has been linked to cancer development and progression. Based on these important functions, there is great interest in developing miRNA based therapeutics. One miRNA, miR-129, has been shown to have important roles in colon cancer. Technology Overview: In the interest of developing miR-129 based cancer therapeutics, researchers at Stony Brook University have made a modified miR-129 mimic that shows enhanced abilities to disrupt resistant cancer cell proliferation and induction of cell cycle arrest when compared to unmodified miR-129. This miR-129 mimic also maintains its ability to regulate important miR-129 target genes in cancer stem cells. In mouse models using cancer stem cells, miR-129 mimic has demonstrated therapeutic potential by reducing tumor growth. Based on these findings, there is potential that modified miR-129 modified miR-129 may be a novel therapeutic to improve survival of advanced stage colon cancer patients. #### Stage of Development _In-vitro_ and _in-vivo_ data. Advantages: More potent, less toxic and higher specificity than current therapeutic agent. Applications: Cancer therapeutics Intellectual Property Summary: Patent application submitted Stage of Development: Provisional filed Licensing Potential: Licensing Licensing Status: Available for License #8859 Additional Information: cancer,colon cancer,cancer biology,mirna,cell proliferation,cell cycle,cell cycle arrest,therapeutic agent,mirna therapy,microrna,microRNA therapeutics,micro rna ,rna,rna therapeutic,rna therapy,cancer therapeutic,cancer therapies,cancer therapy,cancer treatment,oncology,oncology therapeutic,oncology therapy,cancer cells,cell cycle inhibition,oncogene,oncogenes,cancer gene therapy,cancer genetics,cancer genome,cancer stem cells,tumour,precursor,carcinoma,colorectal cancer,therapeutics,stem-cells,tumor growth,survival,_he_5.jpg Please note, header image is purely illustrative. Source: Patho, Wikimedia Commons, CC BY-SA 3.0
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