Oxidized Graphene Nanoribbons as Vectors for Gene Delivery

Targeted delivery and release of genes (DNA/RNA) for therapeutic and research applications.

Therapeutic gene delivery allows replacement of a mutated gene, production of therapeutic proteins inside target cells, delivery of inhibitory RNA for down-regulation of a mutated or over-expressed gene Gene therapy for many diseases including cancer, hemophilia, sickle cell anemia, cystic fibrosis and Alzheimer’s’ disease are under various stages of investigation. Naked genetic material has a very short serum half life due to rapid breakdown by nucleuses resulting in their low bio-availability and entry into target cells.

Dr. Balaji Sitharaman, Associate Professor at Stony Brook University has discovered that oxidized graphene nanoribbons (O-GNR) can be used as gene transfection vectors. O-GNR can be loaded with approximately 2 to 3 times more genetic material than its current alternatives. Also, the toxicity of O-GNR is significantly lower compared to currently used viral and non-viral delivery agents. O-GNR can enter the nucleus by inducing nuclear invaginations resulting in high transfection efficiency in both dividing and non-dividing cells. The commercial applications will be targeted delivery and release of genes in cells or tissues for therapeutic applications, or in cell lines for research applications.

The amount of gene loaded and delivered is typically around 2 to 3 times higher The toxicity is significantly lower compared to currently used delivery agents High transfection efficiency in cells Easily functionalized

Targerted delivery and release of genes (DNA/RNA) for therapeutic and research applications

PCT application filed

preclinical

Available for licensing within certain fields

Exclusive License - Partial Fields

Oxidized graphene nanoribbons, DNA, RNA, Endosomal escape, Nuclear delivery

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