Supramolecular System for Passive Binding and Intracellular Transport of Hydrophobic Biologically Active Substances

Currently, the increase in the bio availability of drugs is achieved by modification of biologically active substances using chemical bond formations poly (ethylene glycol) or PEGylation. Background: The supramolecular approach, subject to this invention does not require chemical bond formation for the drug coating and shows the best performance among the material of this kind. Technology Overview: Supramolecular (micellar system) with hydrophilic shell of linear aliphatic poly (ether) and hydrophobic core of perfectly branched poly (benzyl ether). Advantages: The system can bind a broad variety of hydrophobic substances ranging from small spherical molecules to modestly large linear chains without the necessity of chemical bond formations. Applications: This micellar system has possibility to modulate the surface functionalities in the corona for targeted drug delivery and cell labeling. Intellectual Property Summary: Stage of Development: Licensing Potential: We seek to develop and commercialize, by an exclusive or non-exclusive license agreement and/or sponsored research, with a company active in the area. Licensing Status: Available for License Additional Information: Materials Science and Engineering Block copolymer, drug delivery system, micelles, sustained drug delivery https://stonybrook.technologypublisher.com/files/sites/drug-delivery1.jpg , https://stonybrook.technologypublisher.com/files/sites/material-and-composition1.jpg
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