System And Method for Promoting Cellular Activities for Tissue Repair and Regeneration

Fluid flow induced by mechanical loading has been shown to regulate cell proliferation, cell differentiation, gene expression and second messenger signal production. Background: Discoveries in tissue engineering have uncovered biological mechanisms and conditions necessary to active mechanisms for tissue regeneration and healing. Technology Overview: Stimulating cell activity within a body includes locating a region of interest within the body, locating a non-invasive ultrasound array transucer having a plurality of transucer element on the body in the vicinity of the region of interest. The transucer elements emit acoustic energy sequentially in spatial directions, repeating the process in the second spatial direction at a sweep frequency rate. Fluid flow induces sheer stress within the tissue. Technology is aimed to generate local acoustic force within live tissue to generate dynamic fluid flow and initiate regeneration. Advantages: Fluid flow creates a pressure gradient, which plays a role in stimulating cell response, cellular signal transmission and transfer of nutrients any oxygen to the cells. Applications: Intellectual Property Summary: Stage of Development: Licensing Potential: We seek to develop and commercialize, by an exclusive or non-exclusive license agreement and/or sponsored research, with a company active in the area. Licensing Status: Available for License Additional Information: Biomedical Engineering bone remodeling, bone fluid flow, ultrasound, array transducer, acoustic radiation force, bone adaption, shear stress, low-intensity ultrasound , , ,
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