Treating acute spinal cord contusion injury with repeated x-ray microbeam irradiation

Spinal cord cotusion injury leads to paralysis. Proposed is a method in which x-ray microbeams deliver therapeutic radiation to a contusion.

Microbeams are known to be tissue-sparing as shown by experiments in the US and in Europe with synchrotron generated x-ray microbeams.

Implementations consist of subject undergoing irradiated via x-ray microbeams at about 2,5 and 12 days post-injury. Source of spot size used in development stage for irradiations was 3mm. The method can be used to treat acute contusion injury in the spinal cord of patients. The subject is then closely monitored after irradiations by periodic MR imaging and functional testing to assure there is no radiation damage.

There is currently no existing product that treats acute spinal cord contustion injury. Therefore the advantages of the proposed method are not challenged by any other method.

Radiology

Working prototype available for demonstation.

We seek to develop and commercialize, by an exclusive or non-exclusive license agreement and/or sponsored research, with a company active in the area.

Other (See Additional Information)

Stony Brook University Cancer Center, Neurology, Radiation Oncology

Radiation therapy, x-ray microbeams, tissue-sparing effect, computer tomography (CT) scanner, axon, immune cells, macrophages, micrglia, T-lu,phocyte, B-lumphocyte, neutrophilis, MHC-II expressing cells, progeinitor glil cell, remyelination

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