Methods, Devices, and Systems for Microfluidic Stress Emulation

Point of care devise designed to monitor the efficacy of anti-thrombotic drugs regimens mandated for patients implanted with blood recirculating cardiovascular devices. Background: Mechanical circulatory support devices have emerged in recent years as significant, effective, and therapeutic systems providing restoration of hemodynamics for patients with progressive, advanced, or end-stage heart failure. However use of these devices has been impaired by device-associated thrombosis, which can reduce or stop device function and cause recurrent heart failure, systemic emboli, possible stroke, and death in patients. This device monitors the efficacy of anti-thrombotic drugs regimens mandated for patients implanted with blood recirculating devices in order to tailor the therapy to the patient's needs. Technology Overview: Dr. Bluestein, Professor in the Department of Biomedical Engineering in Stony Brook University created a device designed to monitor the efficacy of anti-thrombic drugs regimens for patients implanted with blood recirculating cardiovascular devices in order to tailor therapy to the patient's needs. This device uses a method related to monitoring the thrombogenic state in a patient treated with a medical device, comprised of modeling the shear stress profile of the medical device; reproducing the shear stress profile of the medical device in a micro-fluidic device; flowing a sample from the patient through the micro-fluidic device; and testing the thrombogenic potential of the sample to monitor the thrombogenic state of the patient. Advantages: Measures anti-thrombic drug efficacy under actual blood flow and shear conditions associated with a specific ventricular assist device. Applications: Monitoring the efficacy of anti-thrombotic drugs regimens mandated for patients implemented with blood recirculating cardiovascular devices. Intellectual Property Summary: Provisional Pending Stage of Development: Prototype developed and available for testing. Licensing Potential: We seek to develop and commercialize, by an exclusive or non-exclusive license agreement and/or sponsored research, with a company active in the area. Licensing Status: Available for License Additional Information: Cardiovascular diseases cardiovascular devices thrombosis platelets blood flow microfluidic device anti thrombic therapy https://stonybrook.technologypublisher.com/files/sites/research-tools-and-reagents1.jpg
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