Spinal Cord Fiber Optic Blood Flow & Oxygenation Monitor

A fiber optic device that allows for the immediate detection of changes in spinal cord blood flow and oxygenation Background: Spine trauma, as a result of motor vehicle accidents, falls, violence, and sports activities, is a global problem. Rates vary from 12-60 cases/million, with annual costs in the United States approaching $10,000,000,000/yr. In addition to this, many patients, adult and pediatric, suffer neurological injury secondary to vascular procedures, resection of spinal cord tumors, and as a result of attempts at the correction of acquired spine deformities. Sixty-five percent of those who present with spinal cord injury (SCI) are potentially amenable to intervention, as only 35% of all SCIs are complete. Hypotension, hypoxia, vasospasm, inflammation, edema, and hemorrhage all propagate spinal ischemia after injury. Prevention of secondary injury from ischemia may limit the severity of subsequent disability. Preventing secondary injury to the spinal cord, as with the brain, requires continued hemodynamic support and often, early surgical intervention. Prevention of secondary spinal injury is focused, to a large degree, upon the preservation or restoration of spinal cord blood flow and oxygen delivery. Technology Overview: While ongoing ischemia plays a prominent role in secondary spinal cord injury, no technology is available to directly and continuous measure or monitor the impact of interventions directed at improving flow and oxygen delivery to resolve the ischemia. Current methods employed to detect spinal cord ischemia, based upon electrophysiology, are indirect, temporally insensitive, nonspecific, and cumbersome. Researchers at Stony Brook University, in collaboration with UPenn, have developed a prototypical fiber optic device based on Diffuse Correlation Spectroscopy (DCS) and Diffuse Optical Spectroscopy (DOS) principles that allows for the immediate detection of changes in spinal cord blood flow and oxygenation. A prototype has undergone limited, but highly successful testing in adult Dorsett sheep. This monitoring tool potentially represents an important step forward, offering a new level of accuracy and immediacy in detecting spinal cord ischemia intraoperatively, and in the neurocritical care setting.

 

State of Development

 

Prototype developed; demonstrated in animal studies on sheep. Data indicates that the device can immediately and sensitively detect the onset of spinal cord ischemia with high reproducibility.

 

Further Details

 

Kogler AS et al “Fiber-optic Monitoring of Spinal Cord Hemodynamics in Experimental Aortic Occlusion” Anesthesiology. 2015 Dec;123(6):1362-73 Advantages: This device measures the spinal cord flow and oxygen level in real time as close to the site of potential injury as possible due to its placement next to the spinal cord. This minimizes the effect of interposing tissue, for example, as compared to skin surface probes.

Placement of probe can be performed via open and percutaneous approaches with proven safety profiles for ‘similar’ devices.

The device can interrogate flow within the entire cross-section of the spinal cord and can be engineered to monitor flow and oxygenation at multiple levels. Applications: Monitoring the onset and progress of spinal cord ischemia

Prevention of secondary ischemic spinal cord injury

Assessment of the efficacy of interventions aimed at ameliorating ischemia

Intraoperative Neuromonitoring- Orthopedic/Neurosurgical spine and spinal cord

Surgery (stabilization for trauma, acquire deformities, tumors), Vascular surgery (aortic repair)

Continuous Neurointensive Care monitoring

Research-Laboratory and clinical assessment of the efficacy of novel therapeutic approaches to ameliorate ischemia. Intellectual Property Summary:Patent application submitted Stage of Development:PCT Application PCT/US2012/069626 entitled “Fiber Optic Flow and Oxygenation Monitoring Using Diffuse Correlation and Reflectance†nationalized in US and EPO. Licensing Potential:Licensing,Development partner Licensing Status:- License via start-up or to established medical device company- Sponsored Research AgreementR-8397  Additional Information: spinal,spinal cord,blood flow,monitoring device,spine,trauma,neurological,injuries,spinal cord injury,SCI,hypoxia,inflammation,hemorrhage,ischemia,surgical,surgical intervention,oxygen delivery,electrophysiology,fibers,fiber-optic,spectroscopy,dcs,optical spectroscopy,probe,ischemic,intraoperative,orthopedic,neurosurgical,surgery,vascular surgery,hemodynamics,anesthesiology,medical devicehttps://stonybrook.technologypublisher.com/files/sites/wl4rfrtvtq2bp3lamuw1_spinal_bruceblaus_wikimedia_ccbysa3.0.pngPlease note, header image is purely illustrative. Source: BruceBlaus, Wikimedia, CC BY-SA 3.0

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