Affinity Purified, Polyclonal Anti-Erlin1 Antibody

Anti-erlin1 is an affinity purified rabbit polyclonal antibody raised against amino acids 332-346 of rat erlin1; EPSGESPIQNKENAG). Erlin1 is a newly-characterized endoplasmic reticulum (ER) membrane protein that forms a complex with erlin2 and has a putative role in a cellular process known as endoplasmic reticulum-associated degradation.  Its official name is endoplasmic reticulum lipid raft-associated protein 1. It has also been referred to as Protein KE04, C10orf69, KEO4, and Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1 (Short name=SPFH domain-containing protein 1 or SPFH1). It recognizes rat and mouse erlin1 (41kDa) in immunoblots, immunoprecipitation and in immunofluorescence microscopy, but not human erlin1. Raising and use of Anti-erlin1 are described in: Pearce, M.M.P., Wormer, D.B., Wilkens, S. and Wojcikiewicz, R.J.H. (2009) An ER membrane complex composed of  SPFH1 and  SPFH2 mediates the ER-associated degradation of IP3 receptors. J. Biol. Chem. 284, 10433-10445.

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