Affinity Purified, Polyclonal Anti-Erlin2 Antibody

Background:

Erlin-2 (endoplasmic reticulum lipid raft associated 2) a member of the SPFH domain-containing family of lipid raft-associated proteins. The protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in the Erlin2 gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

 Technology Overview:

• Polyclonal, affinity-purified
• Immunogen: amino acids 321-339 of rat Erlin-2

 Applications:

 

• Western blot 
• ELISA 
• Immunoprecipitation
• Immunofluorescence assays