Infection-derived monoclonal antibody for use in detecting infectious diseases and bioterrorism agents related to tularemia.
Francisella tularensis is an intracellular, gram-negative bacterium that invades macrophages and initiates the human immune response. Developed by Jorge L. Benach, PH.D., director of the Center for Ingectious Diseases in the Centers for Molecular Medicine, and chair of the Department of Molecular Genetics and Microbiology at Stony Brook University.
Tuleremia, commonly known as "rabbit fever" can be communicated across several species including; rabbits, rodents and humans. Murine monoclonal antibody recognizes a native epitope of Francisella tularensis "Live Vaccine Strain"; IgG monoclonal antibody clone 164 against a native epitope of Francisella tularensis protein, LpnA/Tu14.
The antibody was developed from a mouse infected with F.tularensis live vaccine strain and not recombinant protein, therefore representing a natural antibody made by the mouse in defense of infection against the native F. tularensis protein.
Western blot, ELISA, Immunoprecipitation, Immunoflurescennce assays
Available for License
Monoclonal antibody, F.tularensis LVS, lpnA/Tu14