Development of novel liver-targeting glucocorticoid prodrugs
This technology presents novel liver-targeting glucocorticoid prodrugs designed to improve the treatment of inflammatory liver diseases and sepsis with enhanced efficacy and reduced systemic side effects.
Background:
Inflammatory liver diseases and sepsis represent significant clinical challenges due to their complex immune responses and the difficulty...
Published: 6/12/2026
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Inventor(s): Hong Lu, Juntao Luo, Dandan Guo
Keywords(s): glucocorticoid, inflammatory liver disease, liver-selective, nanoparticle, prodrug, sepsis, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery
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A novel synthetic constitutive-active glucocorticoid receptor
Introducing "superGR," a novel synthetic glucocorticoid receptor fusion protein designed to enhance glucocorticoid therapy by providing ligand-independent activation and improved gene regulation for inflammatory diseases.
Background:
Glucocorticoids are widely used to treat inflammatory conditions like severe alcoholic hepatitis and sepsis, but their...
Published: 3/9/2026
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Inventor(s): Hong Lu, Conor Fahy
Keywords(s): gene therapy, glucocorticoid, inflammatory liver disease, lung injury, sepsis, synthetic materials, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering
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System, Method and Computer-Accessible Medium for Ultralow Dose Computed Tomography Image Reconstruction
Use of systems to create a higher quality, more accurate image Background: Computer tomography (CT) currently operates at high X-ray exposure, in terms of high X-ray flux. These images provide key details into warning such as potential lung cancer in smoking patients, or even possible birth defects in children. However, there are still challenges...
Published: 11/22/2023
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Inventor(s): Zhengrong Liang, Yuxiang Xing, Hongbing Lu, Yongfeng Gao
Keywords(s):
Category(s): Campus > Stony Brook University, Technology Classifications > Diagnostics, Technology Classifications > Computer Software, Technology Classifications > Healthcare IT, Technology Classifications > Medical Imaging
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