Expression of Human Isoferritins

Background:

Ferritin is a molecule resent in mammals, which serves the primary function of sequestering ferrous iron and inducing its mineralization. In mammals, and most saliently in humans, ferritins exist as a co-assembled heteropolymers. Ferritin is produced/extracted using two primary methods: (1) extraction from horse spleen; (2) extraction from E. Coli. Currently, there is no existing method for producing co-assembled ferritin heteropolymers, for mammalian and human use, with modifiable ratios of H and L subunits.

Technology Overview:

This system of expression developed by SUNY Potsdam researchers makes it possible to produce human isoferritins at different desired H-to-L ratios. Different ferritin chains are placed in the same vector, but under the control of different inducible promoters. This method enables the cloning of recombinant ferritin in the pWUR 1+2 tet0 mut89 plasmid. This technology comprises two interrelated methods for cloning ferritin subunits.

Advantages:

• Allows for scalable isoferitin manufacturing
• Enables commercialization of isoferritin to meet increasing demand
• Production at various ratios allows for further studies into human isoferritins

Applications

• Biomedical Science and Engineering
• Medical Devices
• Drug Delivery

Intellectual Property Summary:

US Provisional Filed 62/963,758

Licensing Status:

This technology is available for licensing.

Licensing Potential:

Development partner, Commercial partner, Licensing