Generating Retinal Progenitors by Using the Two Required Transcription Factors

Background:

Generation of autologous pluripotent-derived retinal progenitor cells represents a promising path for treating various disorders associated with vision impairment or blindness. However, the process can still suffer from very long processing times and high costs.

Technology Overview: 

Upstate Medicical University researchers have discovered that the use of Tbx3 and Pax6 transcription factors enables the rapid and cost-effective transformation of human pluripotent cells into retinal progenitors, significantly accelerating the neural differentiation and maturation of the cells.

Advantages:

• Autologous progenitor cell use circumvents the need for immunologically compatible donors
• Faster than current regenerative therapies available
• Cheaper than current therapies

 

Applications:

• Treatment of retinal disorder
• Retinal development and disorder research and testing

• US15/587,254
  
  

  Licensing Status: 

  Available for licensing or collaboration.