Technology - Human Trabecular Organ-on-a-Chip Models

Human Trabecular Organ-on-a-Chip Models

3D biomimetic hydrogel models of the trabecular meshwork of the eye, and a bioengineered system for modelling the conventional outflow tract.


Models of the trabecular meshwork have largely been 2D up until now, but research has shown that 2D models of the TM behave differently -- sometimes in complete opposition -- to 3D models. A 3D model better approximates the actual anatomy of the human tissue, permits more sophisticated experiments, and provides increased accuracy in data-gathering and therapy production to researchers. This trend applies to other models of the eye as well.

Technology Overview:

This technology is a 3D biomimetic hydrogel model of the trabecular meshwork (TM) of the eye, located on a microfluidics chip, intended to be used, for example, to study the relation between the mechanotransduction of the YAP/TAZ proteins and stiffening of the TM cells and extracellular matrix. Stiffening of the TM is associated with primary open angle glaucoma, the most common form of glaucoma. Figure 1 - Complete TM-on-a-chip setup Stage of Development: Technology Readiness Level (TRL) 3 - Analytical and experimental critical function and/or characteristic proof of concept. Bioengineered Human Trabecular Meshwork for Biological Applications This technology is "a system for modeling the conventional outflow tract." Also provided is a method for using the system for screening by contacting the cells with a known or suspected medicament and measuring its effects on the system such as flow of a perfusate. Also provided is a method of making the system by fabricating the porous substrate as a micropatterned scaffold. Figure 2 - An artistic rendering of a bi-layered "artificial TM" 


These two technologies more accurately approximate human 3D tissue anatomy with focus on the cell-ECM interface, and will permit more sophisticated research, clinically relevant drug screening and therapeutic testing, increased accuracy in data-gathering and drug production.


Organ on a chip market and pharmaceutical testing for the eye.

Intellectual Property Summary:

Patent application submitted, Provisional 63/059,965 filed 7/31/20 US 16/044,806 

Stage of Development:

Technology Readiness Level (TRL) 6 - System/subsystem model or prototype demonstration in a relevant environment.

Licensing Status:

These technologies from SUNY Upstate Medical University and SUNY Polytechnic Institute respectively are available for licensing.

Licensing Potential:

Licensing, Commercial partner, Development partner

Patent Information: