Technology - Monolithic Retroreflector Based Detector for PET Imaging

Monolithic Retroreflector Based Detector for PET Imaging

Background:


Positron Emission Tomography (PET) imaging faces significant limitations in cost and performance, particularly regarding achievable spatial resolution. Commercial PET detectors commonly employ pixelated scintillation crystals, which typically yield an average spatial resolution of 4-5 mm. While miniature scintillation crystals are investigated to enhance resolution, they are expensive and challenging to manufacture, requiring numerous photosensors and often resulting in inter-crystal scattering and dead space. Monolithic scintillators present an alternative, being easier to manufacture and free of dead space, but they inherently produce a wider light distribution. Efforts to mitigate this spread, such as using black absorptive surfaces, compromise light collection efficiency and lead to poorer energy and spatial resolutions. Furthermore, previous applications of retroreflectors to improve light collection involved optically coupling a separate retroreflective material, which introduces undesirable distortions, reflections, additional scattering, and inefficiency due to multiple interfaces and differing indices of refraction between materials.

Technology Overview:


Researchers at Stony Brook University developed a PET detector that incorporates a monolithic scintillator with integrated corner retroreflectors (ICR). These trihedral corner reflectors efficiently reflect scintillation light back towards the SiPM array, narrowing the light spread function and substantially increasing the total number of detected photons. This design avoids the dead space and inter-crystal scattering of pixelated arrays, as well as the light collection inefficiencies of monolithic scintillators with absorptive surfaces or the distortions and scattering introduced by optically coupling separate retroreflective materials. The integrated design improves transverse spatial resolution by approximately 30% and significantly enhances depth of interaction capability, particularly at shallow depths, while also improving overall sensitivity by eliminating gaps between crystals.


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Advantages:

  • Reduced manufacturing costs
  • Enhanced sensitivity
  • Improved spatial resolution
  • Better depth of interaction (DOI) resolution
  • Increased light collection efficiency

Applications:

  • Clinical Diagnostic PET Scanners
  • Pre-clinical and Research PET Scanners
  • Hybrid PET/CT and PET/MRI Systems

Intellectual Property Summary:


Utility Application Filed

Stage of Development:


In Silico Data available

Licensing Status:


Available 

Licensing Potential:


Development partner - Commercial partner - Licensing


Patent Information: