Nanocomposite HA-Clay Based Hydrogels

A hyaluronic acid-clay based hydrogel, with applications for cell culture scaffolds in tissue engineering. Background: An approach to tissue engineering includes mimicking the environment of tissue development _in vivo_; this includes the two components of a scaffold and a bioreactor. A scaffold is inserted into a bioreactor, which provides conditions that are similar to _in vivo_ conditions. Scaffolds need to meet specific requirements in order to facilitate cell seeding and diffusion; such requirements include high porosity, adequate pore size, biodegradability, and injectability. Hyaluronic acid (HA) is a naturally occurring polymer found in every tissue of the body, and is a popular option for cell culture scaffolds; however, before the present invention, the HA had to be crosslinked with chemicals for proper mechanical properties. Often, these chemicals are expensive and toxic. Technology Overview: This technology is an inexpensive, non toxic, and biochemically functional HA-hydrogel with improved mechanical stability. The hydrogel is comprised of hyaluronic acid, a nanoclay, and gelatin-type A. The HA is dissolved in a cell culture medium to form a HA solution containing amino acids, salts, glucose, vitamins and an antibiotic. Since this HA hydrogel is clay based, unlike currently available HA hydrogels, it's non-toxic and does not require fibronectin. The gelatin coating promotes cell adhesion and proliferation for well over two weeks. Advantages: -Biodegradable

-Can support cell adhesion

-Do not require fibronectin in order to attach cells

-Less expensive


-HA-hydrogel has biochemical functionality and improved mechanical stability Applications: -Tissue engineering

-Cell culture scaffolds

-Clinical applications Intellectual Property Summary: Patented Stage of Development: [8367117]( Licensing Potential: Development partner,Commercial partner,Licensing Licensing Status: Available for licensing. R-8245 Additional Information: nanocomposite,hyaluronic acid,tissue engineering,cell culture,biodegradable,cell adhesion,biochemical,cell seeding,biodegradability,nanoclay,gelatin,culture medium,glucose,proliferation,hydrogel,polymer,hydrogel scaffold,polymer nanocomposite,nanocomposite material,hyaluronic acid polymer,biocompatible hydrogel,hydrogel synthesis,tissue-hydrogel complex,hydrogel complex,hydrogel formation,cell culture material,tissue culture,human cell culture,tissue scaffolding,tissue scaffold,biomaterial scaffold,tissue engineering scaffold Image is purely illustrative. Source: Flickr/raphaelstrada,, CC BY 2.0.

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