Novel Bioabsorbable Membranes for Cell Delivery Applications

Methods for storing viable cells and for delivering viable cells to a mammal using the cell storage and delivery system. Background: Methods and compositions for encapsulating core materials, e.g., materials containing drugs, have been disclosed. These methods generally involve encapsulating the core material within a micro capsule by forming a semipermeable membrane around the core material. Although a number of processes for micro encapsulation of core material have been developed, most of these processes cannot be used for pH, temperature or ionic strength-sensitive material such as viable cells because of the harsh conditions necessary for encapsulation. Thus, there is a need for improved cell storage and delivery systems which can be produced on an industrial scale, which do not have the above-mentioned disadvantages. Technology Overview: Bio-absorbable polymer membranes are processed by a unique electrospinning technology. The cells can be embedded into the nanostructured membrane during processing. The cell density and the morphology of the membranes can be controlled. The polymer membranes, as a scaffolding material, thus provide the support for localized cell release and growth. These cell-embedded biodegradable membranes may have wide applications in tissue engineering and gene therapy. Advantages: - The Biodegradable membranes provides a support matrix to encapsulate virtually any type of cell (e.g. bone, skin, tissue, and stem) allowing them to be delivered into a specific area. - The cell density, the diameter of fibers, the porosity of the membrane, and the degradation period can be fully controlled by tuning processing parameters. - The cell loading efficiency can be more than 90%. Applications: Tissue engineering and gene therapy.

Support matrix to encapsulate virtually any type of cell.

Cell delivery top a targeted area Intellectual Property Summary: Patented Stage of Development: 8,021,869 7,323,190 Licensing Potential: Licensing Licensing Status: Available for Licensing. 7473 Additional Information: membrane,tissue engineering,cell storage,polymer membrane,membranes,gene therapy,encapsulate,cell delivery,encapsulation,viable cell,drug encapsulation,cell encapsulation,human tissue,living tissue,tissue engineering product,tissue formation,fibre membrane,cell membrane,soft tissue membrane,polymer matrix,methods,industrial scale,stem,porosity https://stonybrook.technologypublisher.com/files/sites/goc1ugfarpmlp9ken0wh_fibres.jpg Please note, header image is purely illustrative. Source: Judyta Dulnik, Wikimedia Commons, CC BY-SA 4.0.

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