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Enzymatic Bioluminescent Beacons for Ultra-Sensitive, Rapid Nucleic Acid Detection

This invention introduces enzymatic bioluminescent beacons that generate bright, low-background light only upon binding their target sequence. A site-specific ligation strategy forms uniform 1 to 1 nanoluciferase–hairpin conjugates, enabling rapid, picomolar sensitivity detection with precise single-base discrimination in streamlined, equipment-light...
Published: 11/14/2025   |   Inventor(s): Brian Callahan
Keywords(s): Technologies
Category(s): Campus > Binghamton University

Traceless Protein–DNA Conjugation for Next-Gen Biotech

This invention introduces a fast, site-specific enzymatic method for attaching oligonucleotides to proteins with near-traceless precision, enabling cleaner, more functional conjugates for diagnostics, therapeutics, and nanotechnology. Background: Conventional methods for protein–oligonucleotide conjugation often suffer from slow reaction rates,...
Published: 11/12/2025   |   Inventor(s): Brian Callahan, Timothy Owen
Keywords(s): #SUNYresearch, Technologies
Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Research Tools and Reagents, Campus > Binghamton University

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