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Concerted, Selective Radiometallation and Photo-triggered Release of Ready-to-Inject Radiopharmaceuticals from the Solid Phase

Solid Phase Radiometallation Photorelease method for the preparation of injectable radiopharmaceuticals RSS.HDBackground> Background: < Radiopharmaceuticals are agents which enable non-invasive patient diagnosis and personalized therapeutic intervention strategies. Radionuclides used in nuclear medicine applications must be purified after nuclear...
Published: 2/4/2025   |   Inventor(s): Eszter Boros, Dariusz Śmiłowicz
Keywords(s):  
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Drug Design and/or Synthesis, Campus > Stony Brook University

Metal-mediated, Autolytic Amide Bond Cleavage for the Selective, Metal-Complexation Catalyzed, Controlled Release of Metallodrugs

Autolytic, metal complex-mediated amide bond cleavage for prodrug activation and synthesis of metallodrugs RSS.HDBackground> Background: < Clinically viable prodrugs release activated drug molecules at the site of interest, requiring close spatiotemporal control. Bond cleavage strategies for the release of the activated drug often incorporate...
Published: 2/4/2025   |   Inventor(s): Eszter Boros, Dariusz Śmiłowicz
Keywords(s):  
Category(s): Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Drug Delivery, Campus, Campus > Stony Brook University

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