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A Nanotrap to Improve Survival in Severe Sepsis by Attenuating Hyperinflammation Through Hemoperfusion

 This optimized nanotrap therapy in combination with a moderate antibiotic treatment resulted in a 100% survival rate in severe septic mice. Background: The mortality rates in severe sepsis patients are 30‑41%. In the U.S. alone, 1.7 million people develop sepsis on a yearly basis. Effective therapies to prevent or treat the cytokine storm or septic...
Published: 1/8/2025   |   Inventor(s): Juntao Luo, Lili Wang, Changying Shi
Keywords(s):  
Category(s): Campus > Upstate Medical University, Technology Classifications > Nanotechnology

Novel Nanocarrier for Systemic and Intracellular Delivery of Biological Therapeutics

 Novel nanocarrier for systemic and intracellular delivery of biological therapeutics. Background: The stability and PK profile are of general concern for in vivo applications of many peptide/protein therapeutics. Poor stability of protein drugs can trigger immunogenicity. Furthermore, peptide and protein therapeutics mostly target extracellular receptors/signaling...
Published: 1/8/2025   |   Inventor(s): Juntao Luo, Changying Shi, Lili Wang
Keywords(s):  
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines

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