Engineered Telodendrimer Nanocarriers for Monomeric Amphotericin B Delivery
A nanocarrier platform for Amphotericin B that improves efficacy and reduces cost, while decreasing toxicity.
Background:
Systemic fungal infections are an increasingly prevalent health problem. The hydrophobic polyene antibiotic Amphotericin B (AmB) is the drug of choice for these life-threatening invasive fungal infections. Unfortunately, it produces...
Published: 2/12/2024
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Inventor(s): Juntao Luo, Xiaotian Ji, Changying Shi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Nanotechnology, Technology Classifications > Therapeutics and Vaccines
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Injectable Nanogel for Immune Modulation Therapy
A platform for effective therapeutic delivery and immune modulation for effective and quick inflammation control in critical illness, including sepsis.
Background:
Immune modulation therapy is a type of immunotherapy that enhances the body’s immune regulation and homeostasis. This therapy has proved promising for the treatment of some types...
Published: 7/11/2023
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Inventor(s): Juntao Luo, Xiaotian Ji, Changying Shi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
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A Nanotrap to Improve Survival in Severe Sepsis by Attenuating Hyperinflammation Through Hemoperfusion
This optimized nanotrap therapy in combination with a moderate antibiotic treatment resulted in a 100% survival rate in severe septic mice.
Background:
The mortality rates in severe sepsis patients are 30‑41%. In the U.S. alone, 1.7 million people develop sepsis on a yearly basis. Effective therapies to prevent or treat the cytokine storm or septic...
Published: 7/11/2023
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Inventor(s): Juntao Luo, Lili Wang, Changying Shi
Keywords(s):
Category(s): Campus > Upstate Medical University, Technology Classifications > Nanotechnology
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Customized Telodendrimer Nanocarriers for Targeted Drug Delivery for Disease Treatments
A suite of nanocarrier technologies that provide targeted drug delivery of hydrophobic and hydrophilic drugs to specific disease sites.
Background:
Delivery of therapeutic and diagnostic compounds is limited by the lack of efficient carriers to improve in vivo stability, selectivity as well as to reduce immunogenicity. Conventional nanocarrier...
Published: 7/11/2023
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Inventor(s): Juntao Luo, Dandan Guo, Changying Shi
Keywords(s): #SUNYresearch, affinity alkylating agent, autoimmune, autoimmune disease, bioactivity, biocompatible, biomaterials, chemical formulation, chemistry, cisplatin, combintorial conjugated dendrimer, dendritic drug delivery, drug delivery component, drug formulation, Featured, graft rejection, hydrophilic drug, hydrophobic drug, immune modulating, immunogenicity inflammation, inflammatory, inflammatory, inflammatory, inflammatory, inflammatory response, inflammatory response, intracellular delivery, methotrexate, moieties, nanocarriers, nanomedicine, nanoparticle, nanoparticle drug delivery, nanoparticle-enhanced delivery, nanotherapy, polyethylene glycol, polymyxin, targeted biologics delivery, targeted delivery, targeted drug delivery, targeted therapeutic delivery, targeting drug, Technologies, therapeutic drug, topoisomerase, vitamin E
Category(s): Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Healthcare, Campus > Upstate Medical University
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Novel Nanocarrier for Systemic and Intracellular Delivery of Biological Therapeutics
Novel nanocarrier for systemic and intracellular delivery of biological therapeutics.
Background:
The stability and PK profile are of general concern for in vivo applications of many peptide/protein therapeutics. Poor stability of protein drugs can trigger immunogenicity. Furthermore, peptide and protein therapeutics mostly target extracellular...
Published: 7/11/2023
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Inventor(s): Juntao Luo, Changying Shi, Lili Wang
Keywords(s):
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
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Telodendrimer Nanoparticles for Protein Delivery
A nanoparticle-based method for enhanced delivery of protein/peptide therapeutics.
Background:
Biologics, for example protein and peptide-based therapeutics, have poor in vitro shelf stability and in vivo enzymatic stability, which lead to short blood circulating time and contribute to immunogenicity. In addition, biologics are impermeable to biological...
Published: 7/24/2023
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Inventor(s): Juntao Luo, Xu Wang, Changying Shi, Alexa Bodman, Walter Hall
Keywords(s): cancer therapy, lipidoids, nanoparticles, protein delivery, telodendrimers
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Nanotechnology
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