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Targeted Delivery of Dopamine Transporter Genes to Dopamine Neurons (MTA)

An adeno-associated virus vector delivering genes controlled by a tyrosine hydroxylase promoter to dopaminergic neurons. Adeno-associated viruses (AAVs) were created to specifically deliver genes to dopaminergic neurons. The proof-of-principle experiment delivered DAt under the control of a tyrosine hydroxylase promoter in a mouse model of dopamine...
Published: 4/5/2023   |   Inventor(s): Caroline Bass, Patrick Fuller, Raul Gainetdinov
Keywords(s): Technologies
Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > University at Buffalo

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