Enzymatic Pyruvate Depletion as Adjunctive Therapy for the Treatment of Biofilm-Related Infections


This technology utilizes a new approach to modulating the extracellular metabolites of biofilm cells to enhance the ability of antimicrobial agents and/or the immune system to control the growth and persistence of microorganisms in medical settings and aqueous systems.



  • Biodegradable.
  • Non-toxic.
  • Approach capable of targeting resistant biofilm cells.
  • Mechanism of action and experimental data suggest very low likelihood of the emergence of resistance.
  • Can be used synergistically with other antimicrobials and dispersion-inducing compounds.



Binghamton University RB567

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