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Development of SelU Inhibitors as New Antibiotics

Scientists discovered that special chemical modifications on bacterial tRNA help control protein production and stress responses. They have also developed novel compounds that take advantage of this mechanism to produce antibiotic effects. Background: The field of epitranscriptomics focuses on the chemical modifications of RNA molecules, which are...
Published: 1/15/2026   |   Inventor(s): Jia Sheng, Thomas Begley
Keywords(s): antibiotics, inhibitors, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Drug Design and Synthesis

Combining Aminoglycoside Antibiotics and PKZ18 Analogs

Significantly enhances the efficacy of aminoglycosides drugs while reducing the risk of microbial drug resistance. Background: To increase drug efficacy and reduce the risk of the development of resistance to treatment, clinicians often prescribe multiple drugs of different classes in combination. For example, many topical creams use an aminoglycoside...
Published: 10/24/2025   |   Inventor(s): Ville Väre, Kathleen McDonough, Ryan Schneider, Paul Agris, Thorsten Seyler
Keywords(s): antibiotics, antimicrobial, drug development, Staphylococcus aureus, synergistic interaction, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines

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