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Tumor-pH–Triggered Doxorubicin Prodrug with On-Demand Shelf-Stable Precursor

This invention introduces a small-molecule doxorubicin prodrug that remains inert in blood and rapidly activates in the mildly acidic tumor microenvironment. Featuring a shelf-stable maleimide pre-prodrug that converts on demand to the ultra-acid-labile DMA form, it enables targeted chemotherapy with improved selectivity, scalable synthesis, and reduced...
Published: 10/10/2025   |   Inventor(s): Ming An, Lan Yao, Vladyslav Nazarenko
Keywords(s): Technologies
Category(s): Campus > Binghamton University

Method for In Vivo Detection of Cell-Surface Disease Markers

A pair of compatible reagents, one antibody-based biomarker target and one small molecule PET tracer, combine to provide a high affinity, disease specific detection system. Background: The medical diagnostics industry has an urgent demand for efficient non-invasive biomarkers to diagnose and stage disease progression for cancer and Alzheimer's...
Published: 10/22/2025   |   Inventor(s): Qing Lin, Ming Fang, Gangam Kumar
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications, Technology Classifications > Healthcare, Technology Classifications > Medical Imaging

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