Targeted Legumain-Cleavable Top1i ADC Platform
Tech Briefs: RSS Drafter said:
This technology introduces a legumain-cleavable antibody drug complex (ADC) that delivers topoisomerase inhibitors directly into tumor cells using a short, polar linker design. The platform employs low-potency Top1i derivatives that maintain strong in vivo efficacy while potentially improving safety, offering a balanced...
Published: 12/10/2025
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Inventor(s): Lawrence Tumey, Nicholas Bianchi, Victor Ojo
Keywords(s): Technologies
Category(s): Campus > Binghamton University
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