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Hydrophilic Asn-Asn-Linker Adcs for Potent and Stable Targeted Immunotherapy

This invention introduces hydrophilic TLR7 agonist antibody drug conjugates using a short Asn Asn linker that improves solubility, stability, and pharmacokinetics. By enabling precise site specific conjugation with reduced aggregation and strong innate immune activation, the platform delivers potent antitumor responses across multiple solid tumor indications. Background:...
Published: 11/14/2025   |   Inventor(s): Lawrence Tumey, Mohan Mullapudi
Keywords(s): Technologies
Category(s): Campus > Binghamton University

Dual Payload Antibody Conjugates for Combined Cytotoxic and Immune Stimulatory Cancer Therapy

This invention introduces a dual payload antibody drug conjugate platform that delivers both a potent cytotoxic agent and a TLR7 agonist to tumors with controlled, site specific attachment. By uniting targeted cell killing with localized immune activation in a single biologic, the approach improves therapeutic index, overcomes resistance, and enhances...
Published: 11/14/2025   |   Inventor(s): Lawrence Tumey, Victor Ojo
Keywords(s): Technologies
Category(s): Campus > Binghamton University

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