Dual isotope labeled Alanines as imaging agents for chronic diseases detection
Novel PET tracers for detecting chronic diseases with improved specificity for detecting bacterial infection
Background:
Positron emission tomography (PET) is a non-invasive, functional imaging technique that is used to monitor metabolic processes and diagnose diseases including cancer and bacterial infections. Fluorodeoxyglucose (FDG) is the most...
Published: 7/28/2025
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Inventor(s): Wenchao Qu, Kaixuan Li, Peter Tonge
Keywords(s):
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Imaging, Campus > Stony Brook University
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LpxC Inhibitors for Gram-Negative Infections
Treatment of multidrug-resistant bacterial infections with LpxC inhibitors for reduced drug resistance and improved safety profiles
RSS.HDBackground> Background: <
Infection by Gram‑negative bacteria such as Pseudomonas aeruginosa, β‑lactamase producing (ESBL) Enterobacteriaceae, and Acinetobacter baumannii is a major health problem, especially...
Published: 7/25/2025
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Inventor(s): Peter Tonge, Fereidoon Daryaee, Sneha Basak
Keywords(s):
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and Synthesis
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Positron Emission Tomography (PET) Radiotracer
Composition, method and diagnostic use of positron imaging tomography imaging agent for bacterial infection detectionRSS.HDBackground> Background: <Positron emission tomography (PET) radiotracer is a diagnostic tool to detect bacterial infection in humans. A deficiency exists in clinical diagnostic tools capable of identifying bacterial infections...
Published: 7/28/2025
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Inventor(s): Peter Tonge, Yong Li, Fereidoon Daryaee, Peter Smith-Jones, Labros Meimetis
Keywords(s):
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Imaging, Technology Classifications > Research Tools and Reagents, Campus, Campus > Stony Brook University
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A Novel PET Imaging Agent for Diagnosing Bacterial Infections
A PET tracer, [18F]F-PABA which is taken up only by bacterial cells thus making it specific for diagnosing infection. Background: Bacterial infections such as those of prosthetic joints, bones (osteomyelitis) and heart valves (infective endocarditis) are difficult to diagnose and treat, and are a major cause of mortality, morbidity and health care...
Published: 5/23/2025
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Inventor(s): Peter Tonge, Zhuo Zhang, Peter Smith-Jones, Hui Wang, Li Liu
Keywords(s): Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Diagnostics, Technology Classifications > Research Tools and Reagents
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