Potent Melatonin Receptor Ligands
Novel compounds for modulation of MT1 and/or MT2 receptor activity
Background:
Melatonin is an indoleamine hormone produced by the pineal gland. It is known primarily for its critical importance in regulating sleep promotion and circadian rhythms, however melatonin has also been implicated in a broad range of unique functions. These include: regulation...
Published: 9/3/2026
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Inventor(s): Margarita Dubocovich, Andrew Tsotinis, Vasiliki Tsalakidou, Aikaterini Sakellaropoulou, Ioannis Papanastasiou, Marina Boniakou
Keywords(s): Featured, Pharmaceutical, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Therapeutics and Vaccines
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Novel Antifungal Agents with Dual Mechanism of Action
With a clear and growing unmet need, a novel mechanism of action, and demonstrated in vitro superiority over current standard-of-care agents, these novel boron-based antifungal agents represent a compelling early-stage opportunity with significant commercial and public health relevance.
Background:
Invasive fungal infections caused by opportunistic...
Published: 8/31/2026
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Inventor(s): Bhaskar Das, Joshua Nosanchuk, Daniel Miranda
Keywords(s): Chemistry, Featured, Healthcare, Pharmaceutical, Research Tool, Screening, Technologies, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Drug Design and Synthesis, Technology Classifications > Therapeutics and Vaccines
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Novel Small Molecule Agents for Glioblastoma
Brain-penetrant small molecule agents possessing a dual targeting mechanism of action (LonP1 and CT-L proteasome inhibition) that may overcome resistance mechanisms that currently plague standard of care treatments for brain tumors such as glioblastoma.
Background:
Malignant astrocytomas, including glioblastoma (GBM), represent highly aggressive intracranial...
Published: 8/31/2026
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Inventor(s): Bhaskar Das, Daniela Bota
Keywords(s): Chemistry, Nanotechnology, Pharmaceutical, Research Tool, Screening, Technologies, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Drug Design and Synthesis, Technology Classifications > Therapeutics and Vaccines
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Method to Determine Quality of Mitochondrial Cargo in Extracellular Vesicles
A novel method that measures mitochondrial membrane potential in extracellular vesicles, providing a direct readout of mitochondrial quality and utility.
Background:
Studies have shown that EV-mediated intercellular communication is influenced, at least in part, by the mitochondrial cargo contained within EVs. This highlights the importance of rigorous...
Published: 8/31/2026
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Inventor(s): Barbara Alevriadou, Zahid Manzar, Hans Minderman
Keywords(s): Biotechnology, Diagnostic, Healthcare, Pharmaceutical, Research Tool, Technologies, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
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