Microenvironments for Self-Assembly of Islet Organoids from Stem Cell Differentiation

Human pluripotent stem cells (hPSCs) are promising cell source to produce therapeutic endocrine cells for diabetes treatment. In spite of intense efforts made to enhance hPSC β-cell differentiation over the past decade, niches inducing the in vitro self-assembly of islet organoids from hPSCs have yet to be identified. This technology significantly promotes three-dimensional islet-like organogenesis during induced hPSC differentation into endocrine lineages. Importantly, cells derived from hPSCs exhibit similar cellular composition to native pancreatic islets.


Differentiation of functional islet organoids.


Binghamton University RB529

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