Non-invasive, In Vivo Enhancement of Immune Function and Immunotherapy by use of Low Intensity Vibration
A safe, non-invasive therapeutic strategy for augmenting immune function in an aging population
Background:
A primary consequence of aging is the progressive dysfunction of the immune system, which leaves the subject population more vulnerable to infection, illness, and cancer. This dysfunction can be attributed, in part, to a reduction in T cell...
Published: 11/3/2025
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Inventor(s): Clinton Rubin, Christopher Ashdown
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Category(s): Technology Classifications > Medical Devices, Campus, Campus > Stony Brook University
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Acceleration of Human T Cell Expansion In Vitro Using Low Intensity Vibrations to Improve Biomanufacturing Process
In-vitro Human T-Cell Expansion to Improve Bio-manufacturing Process
Background:
The CAR T cell therapy process, from patient apheresis to manufacturing facility and back to the treatment center, currently takes anywhere between 2-4 weeks and necessitates a complex network of transportation, scheduling and skilled labor to be successfully executed....
Published: 7/24/2025
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Inventor(s): Mei Lin (Ete) Chan, Clinton Rubin
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Category(s): Technology Classifications > Medical Devices, Campus > Stony Brook University
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Enhancing Responses to Chemical Interventions by Programmed Introduction of Multiple Refractory Periods
A medical device that can deliver multiple, brief intervention doses over a 24 hour period that improves cell biologic responses. Background: The ability of any exogenous intervention, be it physical or chemical in nature, to influence cell activity is markedly enhanced by incorporating a rest period between stimulation periods within any given...
Published: 7/25/2025
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Inventor(s): Clinton Rubin
Keywords(s): Adaptation, Adipogenesis, Adult Stem Cells, Augmentation, Bioelectrical, Bioengineering, Biological, Biomechanical, Biomedical or Biotechnology, Device, Enhancement, Intervention, Mechanical, Mesenchymal Stem Cells, Non-invasive, Osteogenesis, Pharmaceutical, Repair, Stimulation, Technologies, Timing, Tissue
Category(s): Campus > Stony Brook University, Technology Classifications > Medical Devices
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Scanning Confocal Acoustic Diagnostic for Bone Quality
A system for determining at least one bone property of a bone sample Background: This invention deals generally with the diagnostic methods and apparatus for determining the quality and condition of bones and sample materials. The methodology supporting this technology is for determining invasively, destructively the condition of certain bones in...
Published: 11/25/2024
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Inventor(s): Yi -Xian Qin, Wei Lin, Clinton Rubin
Keywords(s):
Category(s): Campus > Stony Brook University, Technology Classifications > Medical Imaging, Technology Classifications > Medical Devices
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