Alternative to Antibody Drug Conjugates
Antibody Drug Complexes (ADCx) that serve as potentially safer alternatives to traditional Antibody Drug Conjugates (ADCs).
Background:
While ADCs have seen some success in the market, toxicity issues have limited the class from reaching its full potential. Toxicity of these agents stems from exposure of their payloads (e.g. auristatin), primarily...
Published: 3/8/2024
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Inventor(s): Brandon Bordeau, Joseph Balthasar
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Drug Delivery
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Compositions and Methods for Increased Circulation Half-Life
Single domain antibody composition that enable half-life extension and increased blood:tissue ratios.
Background:
While strategies such as PEGylation (PEG, polyethylene glycol), albumin binding, and Fc-fusion have been employed to extend the half-life of biological and pharmaceutical agents, there remains a need for additional strategies that not...
Published: 2/2/2024
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Inventor(s): Brandon Bordeau, Joseph Balthasar, Toan Nguyen
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Therapeutics and Vaccines
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Targeted delivery of matrix-modulating enzymes
For enhanced monoclonal antibody uptake and distribution in solid tumors.
Background:
Penetration of anti-tumor therapies is often limited by the tumor microenvironment, which can include a high density of extracellular matrix as well as elevated interstitial fluid pressure, both of which create a barrier to distribution. It is well established...
Published: 2/2/2024
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Inventor(s): Joseph Balthasar, Brandon Bordeau
Keywords(s): Technologies
Category(s): Technology Classifications, Technology Classifications > Antibodies, Technology Classifications > Therapeutics and Vaccines, Campus > University at Buffalo
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