Improving the sensitivity and range of detection with ligation of DNA nanoswitches
This technology uses enzymatic ligation in DNA nanoswitches to detect very short or rare DNA and RNA sequences with high sensitivity, amplifying signals by recycling targets so even single molecules can be identified for diagnostics and research.
Background:
Nucleic acid detection is a cornerstone of modern molecular biology, diagnostics, and biotechnology,...
Published: 3/26/2026
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Inventor(s): Kenneth Halvorsen, Jibin Punnoose, Vinod Morya
Keywords(s): DNA nanoswitches, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Diagnostics, Technology Classifications > Biomedical Science and Engineering
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A 3D printable mini-gel electrophoresis system and methods for use
This technology is a low-cost, 3D printable mini-gel electrophoresis system with built-in electrodes, enabling rapid, portable DNA analysis using battery power—ideal for education, fieldwork, and labs with limited resources.
Background:
Gel electrophoresis is a cornerstone technique in molecular biology, widely used for the separation and analysis...
Published: 3/26/2026
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Inventor(s): Kenneth Halvorsen, Andrew Hayden, Vinod Morya
Keywords(s): 3D printing, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics
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Expanding DNA nanoswitch utility with detection by aptamers
This technology integrates aptamers into DNA nanoswitches, enabling sensitive detection of a wide range of biomolecules—including proteins and small molecules—for use in diagnostics, research, and biosensing applications.
Background:
Molecular detection technologies are foundational in fields such as diagnostics, biomedical research,...
Published: 3/26/2026
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Inventor(s): Kenneth Halvorsen, Arun Richard Chandrasekaran
Keywords(s): aptamers, DNA nanoswitches, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Diagnostics, Technology Classifications > Biomedical Science and Engineering
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Methods for detecting RNA modifications with DNA nanoswitches
This technology uses DNA nanoswitches to directly and specifically detect RNA modifications, allowing simultaneous identification of multiple modifications in their natural sequence context for research, diagnostics, and drug discovery applications.
Background:
RNA modifications, such as methylation, play critical roles in gene regulation, cellular...
Published: 3/26/2026
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Inventor(s): Kenneth Halvorsen, Iranna Todkari, Andrew Hayden
Keywords(s): DNA nanoswitches, RNA modifications, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Diagnostics, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Design and Synthesis
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Portable Assay for COVID-19 Diagnostic
A low-cost, rapid, and more accurate gel electrophoresis-based assay using DNA nanoswitches for detecting COVID-19 and other viruses.
Background:
Viral diagnostics are of prime importance for testing infection rates and for timely treatment, especially in the case of a pandemic such as the current COVID-19 outbreak caused by the SARS-CoV-2 corona...
Published: 2/10/2026
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Inventor(s): Kenneth Halvorsen, Lifeng Zhou
Keywords(s): DNA, RNA, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Diagnostics
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Ribonuclease-responsive DNA Nanoswitches
A DNA nanoswitch that provides a simple mix-and-read methodology to detect RNases (ribonucleases) in a biological sample.
Background: RNases are involved in many biological processes including neurotoxicity, genome replication and maintenance, immune-suppression, and antitumor activity. RNase inhibitors are also potential drug candidates and biomarkers...
Published: 1/30/2026
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Inventor(s): Kenneth Halvorsen, Arun Richard Chandrasekaran
Keywords(s): DNA, RNA, RNA-switch
Category(s): Campus > University at Albany, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Research Tools and Reagents, Technology Classifications > Diagnostics
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RNA Purification with DNA Nanoswitches
Novel, user-centric technology for detecting and analyzing RNA that accelerates the pace of discovery in RNA research. Background: RNA purification is an important part of biomedical research, and very few tools exist for pulling specific RNAs out of a complex solution. Further, understanding of RNA and its complex roles in biology is constantly evolving....
Published: 1/30/2026
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Inventor(s): Kenneth Halvorsen, Lifeng Zhou
Keywords(s):
Category(s): Campus > University at Albany, Technology Classifications > Diagnostics, Technology Classifications > Research Tools and Reagents
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Design and Use of Multi-targeting DNA Nanoswitches for Increased Sensitivity Detection of Long RNAs
This technology provides a novel method for detecting COVID-19 and potentially other virus-based diseases.
Background:
The COVID-19 pandemic created an unprecedented need for large scale diagnostic testing. Unfortunately, the pandemic also created a number of challenges for traditional in vitro diagnostic techniques. These challenges include reagent...
Published: 2/6/2026
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Inventor(s): Kenneth Halvorsen
Keywords(s): detection, DNA nanoswitches, Sensitivity, Technologies
Category(s): Campus > University at Albany, Technology Classifications, Technology Classifications > Diagnostics, Technology Classifications > Research Tools and Reagents
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