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Chemically Modified AMPA Receptor RNA Aptamers Designed for In Vivo Use

" RNA aptamers as glutamate agonists offer potential therapeutics for a range of neurological disorders RSS.HDBackground> Background: < Neurological disorders are increasingly recognized as major causes of death and disability worldwide. Nearly 500,000 cases of brain tumor, multiple sclerosis, and amyotrophic lateral sclerosis (ALS) are diagnosed...

Published: 1/22/2024 | Inventor(s): Li Niu, Zhen Huang

Keywords(s): Technologies

Category(s): Technology Classifications > Screens and Assays, Technology Classifications > Research Tools and Reagents, Campus, Campus > University at Albany

Potent and Selective Inhibition of a Single AMPA Receptor Subunit by an RNA Aptamer

Inhibitors of AMPA type glutamate ion channels for the treatment of neurological disorders such as ALS, Alzheimer's, and Parkinson's. <.HDBackground>Background: Ionotropic glutamate receptors (iGluRs) play special roles in brain activities, such as memory and learning, and have been implicated in a variety of neurological diseases,...

Published: 1/29/2024 | Inventor(s): Li Niu, Zhen Huang, Yan Han, Congzhou Wang, Jae Seon Park

Keywords(s): RNA, Technologies

Category(s): Technology Classifications > Biomedical Science and Engineering, Campus, Campus > University at Albany

Drug Candidate for ALS

RNA aptamers that focus on glutamate receptors are a potential drug candidate for amyotrophic lateral sclerosis (ALS). Background: Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, is a progressive neuromuscular disease for which there is no cure. The disease attacks motor neurons that run from the brain to the spinal cord...

Published: 1/29/2024 | Inventor(s): Li Niu, Zhen Huang

Keywords(s): ALS, amyotrophic lateral sclerosis, aptamers, drug design, Lou Gehrig's disease, MND, motor neurone disease, RNA

Category(s): Technology Classifications > Biomedical Science and Engineering, Campus > University at Albany

RNA Hydrogel

Created from an RNA with unique sequence through self-assembly, this hydrogel has potential in a range of medical and research applications RSS.HDBackground> Background: < Hydrogels are water-saturated turgid materials used for a wide range of applications such as tissue engineering scaffolds and drug delivery vehicles. Hydrogels are one of...