Inhibition of ITK by Novel SLP76pTYR Targeted Only ITK Signaling and Enhanced Tregs
Facilitates graft-versus-leukemia effect (GVL) while minimizing graft-versus-host disease (GVHD).
Background:
Graft versus host disease (GVHD) remains the second leading cause of death following allogeneic hematopoietic stem cell transplant (allo-HCT). In allo-HCT, mature donor T cells in the donor inoculum play a central role in mediating...
Published: 7/11/2023
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Inventor(s): Mobin Karimi, Alaji Bah
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Healthcare
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