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Inhibition of ITK by Novel SLP76pTYR Targeted Only ITK Signaling and Enhanced Tregs

­Facilitates graft-versus-leukemia effect (GVL) while minimizing graft-versus-host disease (GVHD). Background: Graft versus host disease (GVHD) remains the second leading cause of death following allogeneic hematopoietic stem cell transplant (allo-HCT). In allo-HCT, mature donor T cells in the donor inoculum play a central role in mediating...
Published: 7/11/2023   |   Inventor(s): Mobin Karimi, Alaji Bah
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Healthcare

ABI1 Regulates Transcriptional Activity of Androgen Receptor by Novel DNA and AR Binding Mechanism

Provides new pathways for biomarkers and drug discovery for cancer patients. Background: The gene Abelson interactor protein-1 (ABI1) encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal...
Published: 5/8/2024   |   Inventor(s): Leszek Kotula, Alaji Bah
Keywords(s): DNA, regulation of transcriptional dynamics, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines

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