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KIBRA-PKMzeta Interactions in LTP and Memory Maintenance

This technology offers the potential for developing novel and effective treatments for mood- and memory-related disorders and neuropathic pain. Background: During learning, neurons produce an enzyme called protein kinase M zeta (PKMzeta) which is responsible for (1) maintaining newly strengthened connections between neurons, and (2) memory. PKMzeta...
Published: 4/1/2025   |   Inventor(s): Todd Sacktor
Keywords(s): gene therapy, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines

Novel PKCzeta/PKMzeta Inhibitor

Provides a novel treatment option for neuropathic pain and memory disorders such as post-traumatic stress and addiction. Background: During learning, neurons produce an enzyme called PKMzeta, an autonomously active form of PKCzeta, which is responsible for maintaining newly strengthened connections between neurons and for memory. Numerous memory and...
Published: 4/1/2025   |   Inventor(s): Todd Sacktor
Keywords(s): Technologies
Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > SUNY Downstate Health Sciences University

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