β-Catenin agonists recapitulate the protective effects of genetic stabilization
This technology uses drugs that stabilize β-catenin to boost protective immune cells in the lungs, reducing damage from pulmonary hemorrhage and inflammatory lung diseases by activating a novel immunomodulatory pathway.
Background:
Pulmonary hemorrhage and other inflammatory lung diseases represent significant clinical challenges due to their...
Published: 3/30/2026
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Inventor(s): Mobin Karimi
Keywords(s): gene coding, gene therapies, gene therapy, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biomedical Science and Engineering
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A novel synthetic constitutive-active glucocorticoid receptor
Introducing "superGR," a novel synthetic glucocorticoid receptor fusion protein designed to enhance glucocorticoid therapy by providing ligand-independent activation and improved gene regulation for inflammatory diseases.
Background:
Glucocorticoids are widely used to treat inflammatory conditions like severe alcoholic hepatitis and sepsis, but their...
Published: 3/9/2026
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Inventor(s): Hong Lu, Conor Fahy
Keywords(s): gene therapy, glucocorticoid, inflammatory liver disease, lung injury, sepsis, synthetic materials, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering
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KIBRA-PKMzeta Interactions in LTP and Memory Maintenance
This technology offers the potential for developing novel and effective treatments for mood- and memory-related disorders and neuropathic pain.
Background:
During learning, neurons produce an enzyme called protein kinase M zeta (PKMzeta) which is responsible for (1) maintaining newly strengthened connections between neurons, and (2) memory. PKMzeta...
Published: 3/18/2026
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Inventor(s): Todd Sacktor
Keywords(s): gene therapy, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
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