Raman Spectroscopy for Probing Encapsulation of mRNA in Lipid Nanoparticles
This technology uses deep ultraviolet Raman spectroscopy and advanced data analysis to quickly and non-destructively measure how much mRNA is unencapsulated in lipid nanoparticles, improving quality control for mRNA vaccines and therapeutics without chemical labels.
Background:
Messenger RNA (mRNA) therapeutics, particularly those delivered via lipid...
Published: 6/12/2026
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Inventor(s): Igor Lednev, Alexander Shekhtman, Sergei Reverdatto, Sila Jin, Young Mee Jung
Keywords(s): mRNA, Raman spectroscopy, spectroscopy, statistical analysis, Technologies, therapeutics, vaccines
Category(s): Campus > University at Albany, Technology Classifications > Gene Therapy
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Enhancement of adaptive immune responses by post-inoculation administration of fenretinide (N-(4-hydroxyphenyl)retinamide)
This technology uses fenretinide, a synthetic vitamin A derivative, to boost the body’s adaptive immune response after vaccination or infection, making vaccines more effective, especially for poorly immunogenic agents or immunocompromised individuals, without increasing infection severity.
Background:
The field of vaccine development and immunotherapy...
Published: 6/1/2026
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Inventor(s): Adam Waickman, Stephen Thomas, David Foster, Herbert Slade
Keywords(s): Technologies, vaccine stability, vaccines
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
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Raman Spectroscopy for Testing Stability of RNA-based Vaccines and Drugs
A fast, less expensive, and more reliable method for assessing mRNA degradation in vaccines, that can also be used as a tool for the development of new RNA-based therapeutics.
Background:
The development of mRNA-based vaccines for COVID-19 offers the potential for a new medical paradigm based on RNA technology. Unfortunately, these drugs require...
Published: 1/29/2026
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Inventor(s): Igor Lednev, Alexander Shekhtman, Lamyaa Almehmadi, Sergei Reverdatto
Keywords(s): drug stability, mRNA, mRNA stability, Raman spectroscopy, RNA, Technologies, vaccine stability, vaccines
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
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Zika Virus Vaccine
A killed ZIKA vaccine that prevents infection and is safe for pregnant women.
Background:
Zika virus (ZIKV) is a Flavivirus transmitted by mosquitoes. First discovered in 1947, it remained a minor infectious entity until 2007, when the first large outbreak was reported in Micronesia. Subsequent severe outbreaks in French Polynesia (2013-14)...
Published: 1/30/2026
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Inventor(s): Timothy Endy, Kenneth Eckels
Keywords(s): Technologies, vaccines
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
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