Regulatory BC200 RNA in Beast Cancer
This technology is a novel breast cancer treatment that uses small interfering RNAs to silence BC200 RNA.
Background:
Breast cancer incidence rates have been slowly but steadily increasing over the last two decades. Despite improvements in early detection methods and therapeutic interventions, breast cancer remains a leading cause of cancer death...
Published: 5/13/2025
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Inventor(s): Valerio Berardi, Henri Tiedge
Keywords(s): anticancer therapeutic, biomedical science, regulatory RNAs, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Therapeutics and Vaccines
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Breast Cancer Therapeutic Using BC200 RNA Silencing Methods
This technology is a novel breast cancer treatment that uses small interfering RNAs to silence BC200 RNA.
Background:
Breast cancer incidence rates have been slowly but steadily increasing over the last two decades. Despite improvements in early detection methods and therapeutic interventions, breast cancer remains a leading cause of cancer death...
Published: 5/13/2025
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Inventor(s): Valerio Berardi, Henri Tiedge
Keywords(s): breast cancer, RNA modifications, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Therapeutics and Vaccines
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Treatment of Neuropsychiatric Lupus
Directly targets autoimmune antibodies that cause lupus-related seizures and cognitive impairment. Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disorder with poorly understood etiology and no significantly effective treatment. The Lupus Foundation of America estimates that 1.5 million Americans, and at least five million...
Published: 5/13/2025
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Inventor(s): Henri Tiedge, Ilham Muslimov, Ellen Ginzler
Keywords(s): lupus, regulatory RNAs, seizures, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Therapeutics and Vaccines
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Chip-scale Photonic Processing Neuroprosthetic Detector
A novel technology for optimizing visual prosthetics for individuals with foveal blindness.
Background:
The International Agency for the Prevention of Blindness expects 196 million people to suffer from macular degeneration worldwide in 2020. Millions more will suffer from traumatic ocular injury or glaucoma or other foveal defects. The result will...
Published: 5/13/2025
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Inventor(s): Stephen Macknik, Susana Martinez-Conde, Edward White, Satyavolu Papa Rao, Spyridon Galis, John Carter, Olivya Caballero
Keywords(s): brain, cortex, multi-color spatiochromatic encoding, neural recording, OBServ, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Healthcare, Technology Classifications > Medical Devices, Campus > NY CREATES, Campus > SUNY Polytechnic Institute
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Blocking Covid-19 Virus from Entering the Nares, Nasolaryngeal and Pulmonary Airways Using Ace2 Peptides
Prevents initial COVID-19 infection and neutralizes COVID-19 in an existing pulmonary infection.
Background:
COVID-19 remains one of the primary global health issues facing society today. The economic and social impact of the virus will likely be significant for the foreseeable future. Although effective vaccines have been developed, COVID-19 infection...
Published: 5/13/2025
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Inventor(s): Matthew Pincus, Steven Evans, Fred Friedman
Keywords(s): Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Viral Vectors
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Opioid Tolerance-Abating Treatment
A precision medicine approach blocking formation of analgesic tolerance and reversing analgesic tolerance from chronic opioid administration.
Background
Opiates are commonly prescribed in the US for surgical and other severe pain; and many people also obtain opioids illegally. Opioids work well for acute pain; but for those with chronic pain requiring...
Published: 5/13/2025
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Inventor(s): Alan Gintzler, Nai-Jiang Liu
Keywords(s): Technologies
Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > SUNY Downstate Health Sciences University
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Downstate Cardiac Catheterization Laboratory GeneBank and Biorepository
A biorepository database that contains detailed biological information for African Americans and patients with acute cardiac disease.
Background: A biorepository stores biological specimens and the data associated with each sample. The biorepository data is then made available to scientific research institutions. A key step to ensure the quality of...
Published: 5/13/2025
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Inventor(s): Erdal Cavusoglu, Jonathan Marmur
Keywords(s): Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Biological Materials
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Novel PKCzeta/PKMzeta Inhibitor
Provides a novel treatment option for neuropathic pain and memory disorders such as post-traumatic stress and addiction. Background: During learning, neurons produce an enzyme called PKMzeta, an autonomously active form of PKCzeta, which is responsible for maintaining newly strengthened connections between neurons and for memory. Numerous memory and...
Published: 5/13/2025
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Inventor(s): Todd Sacktor, Mildred Acevedo-Duncan
Keywords(s): Technologies
Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > SUNY Downstate Health Sciences University
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Chromatic Bioluminescence as a Cellular Level Readout System of Neural Activity
This technique could be used to visualize neuronal activity in the brain, in nerves, or in ex vivo systems. Background: Some compounds can emit luminescence in response to changes in intracellular ion concentrations. Neuronal depolarization, and the generation of an action potential, involves an elevation in intracellular calcium, which causes the...
Published: 5/13/2025
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Inventor(s): Stephen Macknik, Susana Martinez-Conde, Nozomi Nishimura, Christopher Schaffer
Keywords(s): bioluminescence, optogenetic brain system, prosthetic vision, restoration of vision, Technologies, visual cortex
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Biomedical Science and Engineering
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Use of 2-Hydroxyoleic Acid for the Treatment of Systemic Lupus Erythematosus and Other Immune Pathologies
A novel B cell tolerance pathway activated by the lipid enzyme sphingomyelin synthases 2 (SMS2).
Background:
Autoimmune diseases such as Systemic Lupus Erythematosus are chronic, painful and debilitating. The Lupus Foundation of America estimates that 1.5 million Americans, and at least five million people worldwide, have some form of lupus. The...
Published: 5/13/2025
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Inventor(s): Chongmin Huan, Christopher Roman, Peiqi Ou
Keywords(s): TAF, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Therapeutics and Vaccines
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