Transcription Factors in B cells as Targets for Therapeutic Modulation in SLE
This technology introduces a novel therapeutic approach for systemic lupus erythematosus (SLE) by modulating specific transcription factors in B cells to restore immune tolerance and prevent autoimmunity.
Background:
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of harmful autoantibodies from self-reactive...
Published: 6/24/2026
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Inventor(s): Christopher Roman, Abhimanyu Amarnani
Keywords(s): autoimmune disease, autoimmunity, drug mechanism, gene expression analysis, immune disease, lupus, molecular pharmacology, targeted therapeutic delivery, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Therapeutics and Vaccines
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Fecal Mitochondrial DNA as a Measure of Intestinal Inflammation
This technology introduces a novel method for detecting and assessing intestinal inflammation by measuring mitochondrial DNA levels in stool samples.
Background:
Intestinal inflammation is a critical indicator of various gastrointestinal disorders such as Inflammatory Bowel Disease (IBD), Environmental Enteropathic Dysfunction (EED), and Necrotizing...
Published: 6/23/2026
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Inventor(s): Thomas Wallach
Keywords(s): anti-inflammatory therapeutic, DNA, inflammation, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Bioinformatics
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Topical Minocycline Ointment Suppresses Allergic Skin Responses
This technology presents a topical minocycline ointment formulated to effectively suppress allergic skin responses and reduce inflammation associated with allergic reactions.
Background:
Allergic skin reactions, such as hives, rashes, and inflammation caused by insect bites or contact with allergens, present common dermatological challenges that...
Published: 6/22/2026
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Inventor(s): Rauno Joks, Helen Durkin (Deceased)
Keywords(s):
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Healthcare
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Suppression of histamine and allergen induced itch and swelling with topical minocycline cream
This invention presents a topical 2% minocycline cream that significantly reduces histamine- and allergen-induced itching and swelling, offering a novel non-steroidal treatment for allergic skin reactions.
Background:
Allergic skin reactions, characterized by itching and swelling, affect many individuals and are commonly managed with steroid-based...
Published: 6/22/2026
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Inventor(s): Rauno Joks
Keywords(s): Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Healthcare
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BKHI Prototype
A survey instrument is a tool used to collect data and information from people, often through questionnaires or interviews.
Background:
Survey instruments are fundamental tools in the fields of social science, market research, public health, and education, among others. They enable researchers and organizations to systematically collect data on attitudes,...
Published: 6/12/2026
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Inventor(s): Montgomery Douglas, Aimee Afable, Carla Boutin-Foster, Margaret Salisu, Mark Hoglund, Gwendolyn Lewis, Tenya Blackwell, Anthony DiVittis
Keywords(s): healthcare, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Computer Software, Technology Classifications > Data
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Use of Blood Nitric Oxide Responses as a Biomarker of Obesity and its Associated Conditions, including Allergy and Asthma
This technology offers a novel method for identifying individuals at increased risk for systemic inflammatory disorders, such as asthma, by measuring intracellular nitric oxide synthase expression in specific immune cells.
Background:
Asthma and other systemic inflammatory disorders often present challenges in effective diagnosis and management due...
Published: 6/12/2026
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Inventor(s): Rauno Joks, Maja Nowakowski, Helen Durkin (Deceased)
Keywords(s): Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Screens and Assays
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THE APNEA ALARM: Biomarkers and a Device to Alarm when Risk of Death from Obstructive Apnea is Immediate
Analyzes electrocardiogram (ECG) data and sounds an alarm when two critical biomarkers exceed thresholds, enabling lifesaving intervention.
Background:
Epileptic seizures can cause laryngospasm sufficiently severe to produce complete airway obstruction. Once occluded, attempts to inhale against a closed airway get progressively stronger until attempts...
Published: 1/30/2026
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Inventor(s): Mark Stewart, Richard Kollmar, Jason Lazar
Keywords(s): Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Healthcare IT, Technology Classifications > Medical Devices
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Regulatory BC200 RNA in Beast Cancer
This technology is a novel breast cancer treatment that uses small interfering RNAs to silence BC200 RNA.
Background:
Breast cancer incidence rates have been slowly but steadily increasing over the last two decades. Despite improvements in early detection methods and therapeutic interventions, breast cancer remains a leading cause of cancer death...
Published: 4/7/2026
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Inventor(s): Valerio Berardi, Henri Tiedge
Keywords(s): anticancer therapeutic, biomedical science, regulatory RNAs, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Therapeutics and Vaccines
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Breast Cancer Therapeutic Using BC200 RNA Silencing Methods
This technology is a novel breast cancer treatment that uses small interfering RNAs to silence BC200 RNA.
Background:
Breast cancer incidence rates have been slowly but steadily increasing over the last two decades. Despite improvements in early detection methods and therapeutic interventions, breast cancer remains a leading cause of cancer death...
Published: 3/9/2026
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Inventor(s): Valerio Berardi, Henri Tiedge
Keywords(s): breast cancer, RNA modifications, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Therapeutics and Vaccines
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Treatment of Neuropsychiatric Lupus
Directly targets autoimmune antibodies that cause lupus-related seizures and cognitive impairment. Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disorder with poorly understood etiology and no significantly effective treatment. The Lupus Foundation of America estimates that 1.5 million Americans, and at least five million...
Published: 1/30/2026
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Inventor(s): Henri Tiedge, Ilham Muslimov, Ellen Ginzler
Keywords(s): lupus, regulatory RNAs, seizures, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Therapeutics and Vaccines
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