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Targeting Alternative N-terminal Kinases

Offers the potential of treating epithelial tumors with therapeutics based on BTK-C, a palmitoylated isoform of Bruton's tyrosine kinase (BTK). Background: Bruton’s tyrosine kinase (BTK) plays an active role in the development, maturation, and signaling of B cells. BTK regulates cell proliferation, survival, and migration in various B-cell...
Published: 4/1/2025   |   Inventor(s): Douglas Conklin, Mostafa Kokabee, Xianhui Wang, Ayesha Tahir
Keywords(s): Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Research Tools and Reagents

Suppression of Therapeutic Escape in Breast Cancer by BTK Inhibition

This technology offers the potential of new and novel cancer treatments based on various inhibitors of protein tyrosine kinases Background: Genes that regulate extracellular growth, differentiation, and developmental signals are commonly mutated in cancers. Protein tyrosine kinases (PTKs) mediate the reversible process of tyrosine phosphorylation,...
Published: 4/1/2025   |   Inventor(s): Douglas Conklin, Xianhui Wang
Keywords(s): breast cancer, cancer, Technologies, therapeutic targets
Category(s): Technology Classifications > Biomedical Science and Engineering, Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Therapeutics and Vaccines

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