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Suppression of Therapeutic Escape in Breast Cancer by BTK Inhibition

 This technology offers the potential of new and novel cancer treatments based on various inhibitors of protein tyrosine kinases Background: Genes that regulate extracellular growth, differentiation, and developmental signals are commonly mutated in cancers. Protein tyrosine kinases (PTKs) mediate the reversible process of tyrosine phosphorylation,...
Published: 9/5/2024   |   Inventor(s): Douglas Conklin, Xianhui Wang
Keywords(s): breast cancer, cancer, Technologies, therapeutic targets
Category(s): Technology Classifications > Biomedical Science and Engineering, Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Therapeutics and Vaccines

Targeting Alternative N-terminal Kinases

 Offers the potential of treating epithelial tumors with therapeutics based on BTK-C, a palmitoylated isoform of Bruton's tyrosine kinase (BTK). Background: Bruton’s tyrosine kinase (BTK) plays an active role in the development, maturation, and signaling of B cells. BTK regulates cell proliferation, survival, and migration in various B-cell...
Published: 11/19/2024   |   Inventor(s): Douglas Conklin, Mostafa Kokabee, Xianhui Wang
Keywords(s): Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Research Tools and Reagents

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