Targeting Alternative N-terminal Kinases
Offers the potential of treating epithelial tumors with therapeutics based on BTK-C, a palmitoylated isoform of Bruton's tyrosine kinase (BTK).
Background:
Bruton’s tyrosine kinase (BTK) plays an active role in the development, maturation, and signaling of B cells. BTK regulates cell proliferation, survival, and migration in various B-cell...
Published: 4/1/2025
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Inventor(s): Douglas Conklin, Mostafa Kokabee, Xianhui Wang, Ayesha Tahir
Keywords(s): Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Research Tools and Reagents
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Suppression of Therapeutic Escape in Breast Cancer by BTK Inhibition
This technology offers the potential of new and novel cancer treatments based on various inhibitors of protein tyrosine kinases
Background:
Genes that regulate extracellular growth, differentiation, and developmental signals are commonly mutated in cancers. Protein tyrosine kinases (PTKs) mediate the reversible process of tyrosine phosphorylation,...
Published: 4/1/2025
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Inventor(s): Douglas Conklin, Xianhui Wang
Keywords(s): breast cancer, cancer, Technologies, therapeutic targets
Category(s): Technology Classifications > Biomedical Science and Engineering, Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Therapeutics and Vaccines
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A Novel PET Imaging Agent for Diagnosing Bacterial Infections
A PET tracer, [18F]F-PABA which is taken up only by bacterial cells thus making it specific for diagnosing infection. Background: Bacterial infections such as those of prosthetic joints, bones (osteomyelitis) and heart valves (infective endocarditis) are difficult to diagnose and treat, and are a major cause of mortality, morbidity and health care...
Published: 9/9/2024
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Inventor(s): Peter Tonge, Zhuo Zhang, Peter Smith-Jones, Hui Wang, Li Liu
Keywords(s): Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Diagnostics, Technology Classifications > Research Tools and Reagents
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