Tumor-pH–Triggered Doxorubicin Prodrug with On-Demand Shelf-Stable Precursor
This invention introduces a small-molecule doxorubicin prodrug that remains inert in blood and rapidly activates in the mildly acidic tumor microenvironment. Featuring a shelf-stable maleimide pre-prodrug that converts on demand to the ultra-acid-labile DMA form, it enables targeted chemotherapy with improved selectivity, scalable synthesis, and reduced...
Published: 10/10/2025
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Inventor(s): Ming An, Lan Yao, Vladyslav Nazarenko
Keywords(s): Technologies
Category(s): Campus > Binghamton University
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One-Pot Wonder. Precision-Crafted Nanocrystals, The Power of Platinum Without the Price.
Title:
One-Pot Wonder. Precision-Crafted Nanocrystals, The Power of Platinum Without the Price.
This invention introduces a one-pot synthesis of Mn-based spinel nanocrystals with {101} facets, delivering high ORR efficiency and durability as a cost-effective, non-platinum catalyst for fuel cells.
Background:
Platinum-based catalysts dominate proton...
Published: 9/24/2025
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Inventor(s): Jiye Fang, Ming Zhou
Keywords(s): Technologies
Category(s): Campus > Binghamton University
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Whole Tissue Protein Mapping
A tool and method for precise, high-throughput spatial mapping of proteins across whole tissue samples.
Background:
Spatial proteomics enables delineation of spatial localization of proteins within cells and tissues. This ability to identify and study the relative location and quantification of one or more proteins, whether ones that are endogenously...
Published: 9/12/2025
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Inventor(s): Jun Qu, Ming Zhang, Min Ma
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Bioinformatics
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Whole Tissue Protein Mapping
A tool and method for precise, high-throughput spatial mapping of proteins across whole tissue samples.
Background:
Spatial proteomics enables delineation of spatial localization of proteins within cells and tissues. This ability to identify and study the relative location and quantification of one or more proteins, whether ones that are endogenously...
Published: 9/12/2025
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Inventor(s): Jun Qu, Ming Zhang, Min Ma
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Bioinformatics
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Method for In Vivo Detection of Cell-Surface Disease Markers
A pair of compatible reagents, one antibody-based biomarker target and one small molecule PET tracer, combine to provide a high affinity, disease specific detection system.
Background:
The medical diagnostics industry has an urgent demand for efficient non-invasive biomarkers to diagnose and stage disease progression for cancer and Alzheimer's...
Published: 9/12/2025
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Inventor(s): Qing Lin, Ming Fang, Gangam Kumar
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications, Technology Classifications > Healthcare, Technology Classifications > Medical Imaging
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Compact and Portable Hyperspectral Spectrometer and Imaging System
A compact and portable hyperspectral spectrometer and imaging system with broad wavelength detection and high resolution.
Background:
Hyperspectral imaging technology has many applications in the imaging of geology, vegetation, the atmosphere, hydrology, and other environments. Traditional spectrometers are composed of several discrete components,...
Published: 9/12/2025
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Inventor(s): Qiaoqiang Gan, Zhenqiang Ma, Zongfu Yu, Zhenyang Xia, Ming Zhou
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Environment, Technology Classifications > Instrumentation, Technology Classifications > Sensors
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Optoelectronic Devices Based on Thin Single-Crystalline Semiconductor Films and Non-Epitaxial Optical Cavities
A novel nanoscale optoelectronic device comprising ultrathin materials with single-crystalline quality providing a strong light-matter interaction with high photon absorption and quantum efficiency.
Background:
Miniaturization of optoelectronic devices offers tremendous performance gain. As the volume of photoactive material decreases, optoelectronic...
Published: 9/12/2025
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Inventor(s): Qiaoqiang Gan, Haomin Song, Zhenqiang Ma, Zhenyang Xia, Zongfu Yu, Ming Zhou
Keywords(s): Technologies
Category(s): Technology Classifications > Electronics, Technology Classifications > Optics and Photonics, Technology Classifications > Energy, Campus > University at Buffalo
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