6-azasteroids with unique activity in mycobacteria
The compound functions as potentiators of several anti-tuberculosis drugs
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One third of the world’s population is infected with tuberculosis (TB). In 2014, there were 1.5 million TB related deaths. There are drugs to combat the bacteria by attacking the bacteria directly. The current recommended treatment...
Published: 5/14/2025
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Inventor(s): Nicole Sampson, Joshua Werman, Tianao Yuan
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Category(s): Technology Classifications, Campus > Stony Brook University, Technology Classifications > Drug Design and Synthesis
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Alkene Isomerization as an Entry to Efficient Alternating Ring-opening Metathesis Polymerization (iAROMP)
A technique that enables the preparation of long length and low dispersion polymers with an alternating functional group arrangement Background: Most sequence-controlled polymers lack rigorous fidelity or are homopolymers with simple chain microstructures or copolymers, in which the monomer sequence is not precisely controlled. Polymers of imprecise...
Published: 8/28/2024
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Inventor(s): Nicole Sampson, Li Tan, Kathlyn Parker
Keywords(s): alkene isomerization, Grubbs catalyst, ROMP, ruthenium, Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Research Tools and Reagents, Technology Classifications > Drug Design and Synthesis
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Novel Drugs for the Treatment of Tuberculosis
Compounds that increase TB therapy efficacy through a mechanism of action for increased tolerance and decreased therapy duration. Background: One third of the world's population is infected with tuberculosis (TB). In 2014, there were 1.5 million TB related deaths. The current recommended treatment regimen for TB begins with a two-month intensive therapy...
Published: 8/27/2024
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Inventor(s): Nicole Sampson, Xinxin Yang, Tianao Yuan
Keywords(s):
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and Synthesis
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Novel Inhibitors of Matrix Metalloproteinase-9 for Anti-Cancer Drug Development
Inhibitors that target a site on MMP-9's hemopexin domain that are distinct and cannot be functionally substituted for one another. Background: Matrix Metalloproteinase-9 (MMP-9), a type IV collagenase, is linked to cancer progression and metastasis. Despite increased evidence of correlation between MMP-9 and tumor metastasis, no success has been...
Published: 9/27/2024
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Inventor(s): Vincent Alford, Anushree Kamath, Jian Cao, Nicole Sampson, Iwao Ojima, Xiaodong Ren, Monaf Awwa
Keywords(s): Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Research Tools and Reagents, Technology Classifications > Drug Design and Synthesis
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