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Development of a Pediatric Tuberculosis Diagnostic Test

A lipoprotein diagnostic marker for TB disease ideal for a simple diagnostic assay from a finger prick blood or serum Background: The inadequate sensitivity of available organism-based TB diagnostic tools in children, the wide spectrum of disease observed in children, and the non-specific signs and symptoms especially in young and HIV-children,...
Published: 2/28/2024   |   Inventor(s): Nicole Sampson, Xinxin Yang
Keywords(s): antibody, biomarker, diagnosis, ELISA, modified LDL, Technologies, tuberculosis
Category(s): Campus > Stony Brook University, Technology Classifications > Antibodies, Technology Classifications > Diagnostics

Alkene Isomerization as an Entry to Efficient Alternating Ring-opening Metathesis Polymerization (iAROMP)

A technique that enables the preparation of long length and low dispersion polymers with an alternating functional group arrangement Background: Most sequence-controlled polymers lack rigorous fidelity or are homopolymers with simple chain microstructures or copolymers, in which the monomer sequence is not precisely controlled. Polymers of imprecise...
Published: 11/22/2023   |   Inventor(s): Nicole Sampson, Li Tan, Kathlyn Parker
Keywords(s): alkene isomerization, Grubbs catalyst, ROMP, ruthenium, Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Research Tools and Reagents

Degradable Polymeric Materials via Large Ring Alternating Ring Opening Metathesis Polymerization (AROMP)

An effective way of designing a myriad of intelligent materials that are readily degradable and easily synthesized Background: Ring opening metathesis polymerization is a technique which enables the synthesis of materials of diverse architecture owing to its tolerance to a large range of functionalities. Traditionally, the scope of monomers used yields...
Published: 11/22/2023   |   Inventor(s): Nicole Sampson, Jingling Zhang, Francis Boadi, Guofang Li
Keywords(s):  
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Delivery, Technology Classifications > Electronics and Electronic Materials, Technology Classifications > Material and Composites, Technology Classifications > Therapeutics

Novel Drugs for the Treatment of Tuberculosis

Compounds that increase TB therapy efficacy through a mechanism of action for increased tolerance and decreased therapy duration. Background: One third of the world's population is infected with tuberculosis (TB). In 2014, there were 1.5 million TB related deaths. The current recommended treatment regimen for TB begins with a two-month intensive therapy...
Published: 6/5/2023   |   Inventor(s): Nicole Sampson, Xinxin Yang, Tianao Yuan
Keywords(s):  
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis

Novel Inhibitors of Matrix Metalloproteinase-9 for Anti-Cancer Drug Development

Inhibitors that target a site on MMP-9's hemopexin domain that are distinct and cannot be functionally substituted for one another. Background: Matrix Metalloproteinase-9 (MMP-9), a type IV collagenase, is linked to cancer progression and metastasis. Despite increased evidence of correlation between MMP-9 and tumor metastasis, no success has been...
Published: 2/28/2024   |   Inventor(s): Vincent Alford, Anushree Kamath, Jian Cao, Nicole Sampson, Iwao Ojima, Xiaodong Ren
Keywords(s): Technologies
Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Research Tools and Reagents

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